Basic & Clinical Cancer Research is a peer-reviewed, open-access journal that aims to publish the highest quality articles on all aspects of cancer research, including research findings of pathophysiology, prevention, diagnosis and treatment of cancers, and technical evaluations and serves as a discussion forum for cancer scientists.

 

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Current Issue

Vol 13 No 3 (2021)

Original Articles

  • XML | PDF | downloads: 34 | views: 51 | pages: 175-186
    Background: Recently, it has been shown that, piRNAs as a new class of non-coding RNAs (ncRNAs), play crucial roles in germline development and carcinogenesis. Despite this, the study on the effects of piRNAs polymorphism (piR-SNP) on colorectal cancer (CRC) risk is scarce. We evaluate the impact of rs11776042 in piRNA 015551 on CRC initiation and development in the Iranian population. Matherials & METHODS: The association of novel polymorphisms rs11776042 in piRNA 015551 gene with CRC risk using a case-control study on the Iranian population was estimated. All subjects were evaluated by TETRA primer-Amplification refractory mutation system polymerase chain reaction (TP-ARMS- PCR assay) Results: The genotypes frequency was 27%, 68% and 0.05% for C/C, C/T and T/T in controls and 31%, 65% and 0.04% in CRC patients respectively. The frequency of the C allele was 63% in patients versus 61% in controls and, T allele frequency was 37% in patients versus 39% in controls. Conclusion: No significant difference was found in genotype and allele frequencies between the cases and controls for rs11776042 polymorphism in piRNA 015551 in our population.  
  • XML | PDF | downloads: 20 | views: 36 | pages: 187-192
    Background: In March 2020, the World Health Organization declared the novel COVID-19 infection a pandemic. Among high-risk patients infected by the virus, upper gastrointestinal cancer patients similar to other immunosuppressed patients are vulnerable to develop more severe infections. Most of the routine activities of medical centers, especially cancer surgery centers around the world, are affected by this epidemic. Thus, some modifications are needed to adjust international protocols to deal with upper gastrointestinal cancers in all the world. Methods: The headings of upper gastrointestinal cancer management protocols have been discussed among the university-affiliated professors in different disciplines involved in upper gastrointestinal cancer management. The discussions were done through an interactive application (WhatsApp & Telegram) in which participants considered the headlines and the latest news about COVID-19. Under each heading, we provide the consensus of all members in the related disciplines. Recommendations and Conclusion: In each specialty, all members agreed to choose minimal intervention. The members know that some recommendations may interfere with the routine best-practice recommendations and decrease the quality measures in the patient's outcome. Therefore, these recommendations are valid just in epidemic COVID-19 situation. According to the consensus of cancer surgery professors in several cancer surgery centers, gastric cancer  with T1, T2 and T3 but N0 should be upfront operated but in T3 or N1 or more, the surgery after six courses of chemotherapy should be postponed until the end of the COVID-19  Epidemic and in this phase no diagnostic laparoscopy will be performed , but in the esophageal cancer, T1,T2 and N0 should be upfront operated but T3, T4 and N1 or more, a PET-CT scan will be performed. In the status of high uptake and severe dysphagia, the stent placement is reasonable but in low uptake without any dysphagia, only conservation is our suggestion. Keywords: Upper Gastrointestinal Cancers; COVID-19; Outbreak; Cancer Surgery Centers; Consensus
  • XML | PDF | downloads: 11 | views: 14 | pages: 193-200
    This study was conducted to determine effectiveness of group hope training and neuro-linguistic programming (NLP) on hope and quality of life among children with cancer. This was a quasi-experimental research with pretest, posttest, and follow-up consisting of control group. Statistical population consisted of male and female children with cancer referring to Amir Kabir Hospital and Cancer Association of Tabasom during 2016; these children were at age range of 7-18 and demanded to participate in group hope training and NLP sessions. Participants who were at least at first grade, maximally secondary school degree, and were under chemical treatment, were selected as sample members. 60 members were selected using convenient sampling method then assigned randomly to three groups of hope training, NLP training, and control. Children's Quality of Life Questionnaire and Snyder's Children's Hope Scale were used as research instruments. Data analysis was done using MANOVA and ANOVA. Findings indicated a significant difference between hope training and NLP one. Both interventions had almost the same effect on quality of life while group hope training had higher effect on dependent variables. Results showed that LNP group training led to increase quality of life and hope predicting 70% and 40% of their variances, respectively. In addition, findings showed effectiveness of group hope training on increase in quality of life and hope and could predict 53% and 84% of their variances, respectively. According to the findings obtained from study, group LNP training and group hope training could increase quality of life and hope.  
  • XML | PDF | downloads: 3 | views: 3 | pages: 210-224
    Fluorine 18-deoxyglucose (18FDG) is often used in Positron Emission Tomography (PET). PET imaging is one of the useful tool which is used to cancer detection and management. PET growth is limited due to problems that depend on the production of Fluorine-18.Imaging results are strongly dependent on the information of nuclear reaction cross section data. This study is done to calculate the stopping power, RCSDA, simulated and distributed absorbed dose of F-18, in water. In order to access these goals, we use the Geant4/Gate simulation and the Bethe-Bloch theory model. The results of this simulation and this theory model are in good agreement with each other .The main point of this paper is the presentation of a theoretical approach to the production of Fluorine-18 by using protons production through the main nuclear fusion reaction and the side fusion reaction   uses helium-3 as a catalyzed.

Reviews

  • XML | PDF | downloads: 33 | views: 42 | pages: 156-174
    Progress in cancer stem cells has opened up a new window to develop better cancer treatment methods. Several pre-clinical and clinical trial studies use CSCs targeting via surface markers method and inhibition of stem cell pathway to eradicate cancer. Albite, some important question was unclear about CSCs origin and molecular mechanism of self-renewal, the structure of CSCs markers and so on, but the eradication of these cells eliminate cancer. In this review, we have argued about the CSC surface markers on different cancers, the mechanisms of action, and therapeutic procedures related to the cancer biomarkers. Then, we have discussed the challenges of these therapies.
  • XML | views: 13 | pages: 201-209
    Abstract  Backgound: Ovarian cancer, although not possessing a high incidence, is still the most common cancer-related deaths among women diagnosed with a gynecologic malignancy. The present study aims to highlight the epidemiology, risk factors of this disease and the significance of development of improved early detection strategies.  Methods: This study was conducted using current published English studies by searching PubMed. The search strategy included the keywords “ovarian cancer”, “risk factors”, “screening”, “epidemiology”.  Studies on incidence and mortality were also considered. Case reports were excluded. Results: The highest incidence and mortality rates are observed in Central and Eastern Europe, while rates are relatively low in Asia and Africa. These rates are highest among the white population (14.3 per 100,000) and lowest among blacks (10 per 100,000) and Asians (9.7 per 100,000). The risk factors for this disease includes a family history, hormonal factors, nutrition and diet and physical activity, with some of them playing protective roles in reducing risk of ovarian cancers. There are no reliable screening methods for ovarian cancers. The most common diagnosis methods include a transvaginal ultrasound and a blood test to detect CA125 markers. Conclusions: The mortality rate of ovarian cancer is gradually increasing; thus, preventative measures are required to reduce lifetime risk of ovarian cancers and improve mortality rate.
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