CircRNAs as Possible Potential Biomarkers for Breast Cancer Prognosis and Chemotherapy Response: A Comprehensive Study
,
Abstract
Background: Breast cancer is the leading cause of death for women worldwide. Optimal methods for most cancer control require the use of appropriate biomarkers. Recently, circular RNAs (circRNAs), as closed-loop RNA molecules generated through reverse splicing, have emerged as promising biomarkers for cancer development. Methods: In this observation, the expression of 3 unique circRNAs - cdr1as, circRNA-000284, circ-ITCH - within the peripheral blood of breast cancer patients was studied using Real-Time RT-PCR before and after chemotherapy compared with the control. Results: The data confirmed that the analyzed circRNAs expression was significantly altered in breast cancer patients compared to the controls. These alterations have been related to advanced stages, lymph node involvement, and metastasis. CircRNA-000284 expression considerably decreased after chemotherapy. This may proposed its potential as a biomarker for monitoring treatment response. Conclusion: These findings provide valuable insights for the development of novel strategies in the management and treatment of breast cancer. However, further studies are required to validate the clinical utility of these circRNAs as biomarkers and to explore their underlying mechanisms in breast cancer progression.
1. Zhou SY, Chen W, Yang SJ, et al. The emerging role of circular RNAs in breast cancer. Biosci Rep. 2019;39:BSR20190621. doi: 10.3389/fonc.2021.605988. PMID: 33718157; PMCID: PMC7947672.
2. Xu C, Zhang J. Mammalian circular RNAs result largely from splicing errors. Cell Rep. 2021; 36:109439. doi: 10.1016/j.celrep.2021.109439. PMID: 34320353; PMCID: PMC8365531.
3. Zhou WY, Cai ZR, Liu J, Wang DS, Ju HQ, Xu RH. Circular RNA: metabolism, functions and interactions with proteins. Mol Cancer Dec. 2020; 14:19:172. doi: 10.1186/s12943-020-01286-3. PMID: 33317550; PMCID: PMC7734744.
4. Miao Q, Ni B, Tang J. Coding potential of circRNAs: new discoveries and challenges. PeerJ. 2021; 18:9:e10718. doi: 10.7717/peerj.10718. PMID: 33552732; PMCID: PMC7819118.
5. Kristensen LS, Jakobsen T, Hager H, Kjems J . The emerging roles of circRNAs in cancer and oncology. Nat Rev Clin Oncol. 2022; 19:188-206. doi: 10.1038/s41571-021-00585-y. Epub 2021 Dec 15. PMID: 34912049.
6. Mehta SL, Dempsey RJ, Vemuganti R. Role of circular RNAs in brain development and CNS diseases. Prog Neurobiol. 2020; 186:101746. doi: 10.1016/j.pneurobio.2020.101746. Epub 2020 Jan 10. PMID: 31931031; PMCID: PMC7024016.
7. Ju J, Song YN, Chen XZ, Wang T, Liu CY, Wang K. circRNA is a potential target for cardiovascular diseases treatment. Mol Cell Biochem. 2022; 477:417-430. doi: 10.1007/s11010-021-04286-z. Epub 2021 Nov 15. PMID: 34780000.
8. Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019;20:675-691. doi: 10.1038/s41576-019-0158-7. Epub 2019 Aug 8. PMID: 31395983.
9. Xuan L, Qu L, Zhou H, et al. Circular RNA: a novel biomarker for progressive laryngeal cancer. Am J Transl Res. 2016; 8:932-9. PMID: 27158380; PMCID: PMC4846937.
10. Li T, Zuo X, Meng X. Circ_002059 suppresses cell proliferation and migration of gastric cancer via miR-182/MTSS1 axis. Acta Biochim Biophys Sin (Shanghai). 2021; 53:454-462. doi: 10.1093/abbs/gmab015. PMID: 33686422.
11. Qin M, Liu G, Huo X, et al. Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma. Cancer Biomark. 2016; 16:161-9. doi: 10.3233/CBM-150552. PMID: 26600397.
12. Huang G, Liang M, Liu H, Huang J, et al. CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway. Cell Death Dis. 2020; 11:1065. doi: 10.1038/s41419-020-03276-1. PMID: 33311442; PMCID: PMC7734058.
13. Shang X, Li G, Liu H, et al. Comprehensive Circular RNA Profiling Reveals That hsa_circ_0005075, a New Circular RNA Biomarker, Is Involved in Hepatocellular Crcinoma Development. Medicine (Baltimore). 2016; 95:e3811. doi: 10.1097/MD.0000000000003811. PMID: 27258521; PMCID: PMC4900729.
14. Wang X, Zhang Y, Huang L, et al. Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances. Int J Clin Exp Pathol. 2015; 8:16020-5. PMID: 26884878; PMCID: PMC4730091.
15. Guo JN, Li J, Zhu CL, et al. Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer. Onco Targets Ther. 2016; 9:7451-7458. doi: 10.2147/OTT.S123220. PMID: 28003761; PMCID: PMC5158168.
16. Zheng R, Zhang K, Tan S, et al. Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3-eIF3h interaction. Mol Cancer. 2022; 21:49. doi: 10.1186/s12943-021-01471-y. PMID: 35164758; PMCID: PMC8842935.
17. Shang A, Gu C, Wang W, et al. Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-β1 axis. Mol Cancer. 2020; 19:117. doi: 10.1186/s12943-020-01235-0. PMID: 32713345; PMCID: PMC7384220.
18. Jian X, He H, Zhu J, et al. Hsa_circ_001680 affects the proliferation and migration of CRC and mediates its chemoresistance by regulating BMI1 through miR-340. Mol Cancer. 2020; 19:20. doi: 10.1186/s12943-020-1134-8. Erratum in: Mol Cancer. 2024 May 14;23(1):100. doi: 10.1186/s12943-024-02018-7. PMID: 32005118; PMCID: PMC6993513.
19. Chen J, Wu Y, Luo X, et al. Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer. Theranostics. 2021; 11:7507-7526. doi: 10.7150/thno.59546. PMID: 34158864; PMCID: PMC8210600.
20. Hu Y, Song Q, Zhao J, et al. Identification of plasma hsa_circ_0008673 expression as a potential biomarker and tumor regulator of breast cancer. J Clin Lab Anal. 2020; 34: e23393. doi: 10.1002/jcla.23393. Epub 2020 Aug 18. PMID: 32808350; PMCID: PMC7521290.
21. Xu J, Ji L, Liang Y, et al. CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1. Signal Transduct Target Ther. 2020; 5:298. doi: 10.1038/s41392-020-00375-5. PMID: 33361760; PMCID: PMC7762756.
22. Xu J, Wan Z, Tang M, et al. N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling. Mol Cancer. 2020; 19:163. doi: 10.1186/s12943-020-01281-8. PMID: 33222692; PMCID: PMC7681956.
23. Yin WB, Yan MG, Fang X, Guo JJ, Xiong W, Zhang RP. Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection. Clin Chim Acta. 2018; 487:363-368. doi: 10.1016/j.cca.2017.10.011. Epub 2017 Oct 16. PMID: 29045858.
24. Yang W, Yang X, Wang X, et al. Silencing CDR1as enhances the sensitivity of breast cancer cells to drug resistance by acting as a miR-7 sponge to down-regulate REGγ. J Cell Mol Med. 2019; 23:4921-4932. doi: 10.1016/j.cca.2017.10.011. Epub 2017 Oct 16. PMID: 29045858.
25. Ghafouri-Fard S, Khoshbakht T, Hussen BM, Sarfaraz S, Taheri M, Ayatollahi SA . Circ_CDR1as: A circular RNA with roles in the carcinogenesis. Pathol Res Pract. 2022; 236:153968. doi: 10.1016/j.prp.2022.153968. Epub 2022 Jun 1. PMID: 35667198.
26. Ma HB, Yao YN, Yu JJ, Chen XX, Li HF. Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506. Am J Transl Res. 2018; 10:592-604. PMID: 29511454; PMCID: PMC5835825.
27. Rossi M, Inoue S, Walewska R, Knight RA, Dyer MJ, Cohen GM, et al. Caspase cleavage of Itch in chronic lymphocytic leukemia cells. Biochem Biophys Res Commun. 2009; 379:659-64. doi: 10.1016/j.bbrc.2008.11.154. Epub 2008 Dec 13. PMID: 19073138.
28. Huang G, Zhu H, Shi Y, Wu W, Cai H, Chen X. cir-ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/β-catenin pathway. PLoS One. 2015; 10:e0131225. doi: 10.1371/journal.pone.0131225. PMID: 26110611; PMCID: PMC4482251.
29. Wan L, Zhang L, Fan K, Cheng ZX, Sun QC, Wang JJ. Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/β-Catenin Pathway. Biomed Res Int. 2016; 2016:1579490. doi: 10.1155/2016/1579490. Epub 2016 Aug 24. PMID: 27642589; PMCID: PMC5013215.
30. Guo W, Zhang J, Zhang D, Cao S, Li G, Zhang S, et al. Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma. Oncotarget. 2017; 8:48169-48177. doi: 10.18632/oncotarget.18327. PMID: 28636993; PMCID: PMC5564635.
31. Yang C, Yuan W, Yang X, et al. Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression. Mol Cancer. 2018; 17:19. doi: 10.1186/s12943-018-0771-7. PMID: 29386015; PMCID: PMC5793418.
32. Wang M, Chen B, Ru Z, Cong L. CircRNA circ-ITCH suppresses papillary thyroid cancer progression through miR-22-3p/CBL/β-catenin pathway. Biochem Biophys Res Commun. 2018; 504:283-288. doi: 10.1016/j.bbrc.2018.08.175. Epub 2018 Sep 4. PMID: 30190130.
33. Hu H, Wang Y, Qin Z, et al. Regulation of MRP4 Expression by circHIPK3 via Sponging miR-124-3p/miR-4524-5p in Hepatocellular Carcinoma. Biomedicines. 2021; 9:497. doi: 10.3390/biomedicines9050497. PMID: 33946595; PMCID: PMC8147194.
34. Tang Q and Hann SS. Biological Roles and Mechanisms of Circular RNA in Human Cancers. Onco Targets Ther. 2020; 13:2067-2092. doi: 10.2147/OTT.S233672. PMID: 32210574; PMCID: PMC7069569.
35. Huang X, Song C, Zhang J, Zhu L, Tang H. Circular RNAs in breast cancer diagnosis, treatment and prognosis. Oncol Res. 2023;32:241-249. doi: 10.32604/or.2023.046582. PMID: 38186573; PMCID: PMC10765117.
36. Badowski C, He B, Garmire LX. Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty. NPJ Precis Oncol. 2022;6:40. doi: 10.1038/s41698-022-00283-7. PMID: 35729321; PMCID: PMC9213432.
37. Das S, Dey MK, Devireddy R, Gartia MR. Biomarkers in Cancer Detection, Diagnosis, and Prognosis. Sensors (Basel). 2023; 24:37. doi: 10.3390/s24010037. PMID: 38202898; PMCID: PMC10780704.
38. Sang Y, Chen B, Song X, et al. circRNA_0025202 Regulates Tamoxifen Sensitivity and Tumor Progression via Regulating the miR-182-5p/FOXO3a Axis in Breast Cancer. Mol Ther. 2019; 27:1638-1652. doi: 10.1016/j.ymthe.2019.05.011. Epub 2019 May 17. Erratum in: Mol Ther. 2021 Dec 1;29(12):3525-3527. doi: 10.1016/j.ymthe.2021.11.002. PMID: 31153828; PMCID: PMC6731174.
39. Liang HF, Zhang XZ, Liu BG, Jia GT, Li WL. Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Am J Cancer Res. 2017; 7:1566-1576. PMID: 28744405; PMCID: PMC5523036.
40. Zhang J, Xu HD, Xing XJ, Liang ZT, Xia ZH, Zhao Y. CircRNA_069718 promotes cell proliferation and invasion in triple-negative breast cancer by activating Wnt/β-catenin pathway. Eur Rev Med Pharmacol Sci. 2019; 23:5315-5322. doi: 10.26355/eurrev_201906_18198. PMID: 31298383.
41. Chen LL. The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Biol. 2016; 17:205-11. doi: 10.1038/nrm.2015.32. Epub 2016 Feb 24. PMID: 26908011.
42. Tang W, Ji M, He G, et al. Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7. Onco Targets Ther. 2017; 10:2045-2056. PMID: 28435295; PMCID: PMC5391170.
43. Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013; 495:384-8. doi: 10.1038/nature11993. Epub 2013 Feb 27. PMID: 23446346.
44. Clusan L, Ferrière F, Flouriot G, Pakdel F. A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer. Int J Mol Sci. 2023; 24:6834. doi: 10.3390/ijms24076834. PMID: 37047814; PMCID: PMC10095386.
2. Xu C, Zhang J. Mammalian circular RNAs result largely from splicing errors. Cell Rep. 2021; 36:109439. doi: 10.1016/j.celrep.2021.109439. PMID: 34320353; PMCID: PMC8365531.
3. Zhou WY, Cai ZR, Liu J, Wang DS, Ju HQ, Xu RH. Circular RNA: metabolism, functions and interactions with proteins. Mol Cancer Dec. 2020; 14:19:172. doi: 10.1186/s12943-020-01286-3. PMID: 33317550; PMCID: PMC7734744.
4. Miao Q, Ni B, Tang J. Coding potential of circRNAs: new discoveries and challenges. PeerJ. 2021; 18:9:e10718. doi: 10.7717/peerj.10718. PMID: 33552732; PMCID: PMC7819118.
5. Kristensen LS, Jakobsen T, Hager H, Kjems J . The emerging roles of circRNAs in cancer and oncology. Nat Rev Clin Oncol. 2022; 19:188-206. doi: 10.1038/s41571-021-00585-y. Epub 2021 Dec 15. PMID: 34912049.
6. Mehta SL, Dempsey RJ, Vemuganti R. Role of circular RNAs in brain development and CNS diseases. Prog Neurobiol. 2020; 186:101746. doi: 10.1016/j.pneurobio.2020.101746. Epub 2020 Jan 10. PMID: 31931031; PMCID: PMC7024016.
7. Ju J, Song YN, Chen XZ, Wang T, Liu CY, Wang K. circRNA is a potential target for cardiovascular diseases treatment. Mol Cell Biochem. 2022; 477:417-430. doi: 10.1007/s11010-021-04286-z. Epub 2021 Nov 15. PMID: 34780000.
8. Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019;20:675-691. doi: 10.1038/s41576-019-0158-7. Epub 2019 Aug 8. PMID: 31395983.
9. Xuan L, Qu L, Zhou H, et al. Circular RNA: a novel biomarker for progressive laryngeal cancer. Am J Transl Res. 2016; 8:932-9. PMID: 27158380; PMCID: PMC4846937.
10. Li T, Zuo X, Meng X. Circ_002059 suppresses cell proliferation and migration of gastric cancer via miR-182/MTSS1 axis. Acta Biochim Biophys Sin (Shanghai). 2021; 53:454-462. doi: 10.1093/abbs/gmab015. PMID: 33686422.
11. Qin M, Liu G, Huo X, et al. Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma. Cancer Biomark. 2016; 16:161-9. doi: 10.3233/CBM-150552. PMID: 26600397.
12. Huang G, Liang M, Liu H, Huang J, et al. CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway. Cell Death Dis. 2020; 11:1065. doi: 10.1038/s41419-020-03276-1. PMID: 33311442; PMCID: PMC7734058.
13. Shang X, Li G, Liu H, et al. Comprehensive Circular RNA Profiling Reveals That hsa_circ_0005075, a New Circular RNA Biomarker, Is Involved in Hepatocellular Crcinoma Development. Medicine (Baltimore). 2016; 95:e3811. doi: 10.1097/MD.0000000000003811. PMID: 27258521; PMCID: PMC4900729.
14. Wang X, Zhang Y, Huang L, et al. Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances. Int J Clin Exp Pathol. 2015; 8:16020-5. PMID: 26884878; PMCID: PMC4730091.
15. Guo JN, Li J, Zhu CL, et al. Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer. Onco Targets Ther. 2016; 9:7451-7458. doi: 10.2147/OTT.S123220. PMID: 28003761; PMCID: PMC5158168.
16. Zheng R, Zhang K, Tan S, et al. Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3-eIF3h interaction. Mol Cancer. 2022; 21:49. doi: 10.1186/s12943-021-01471-y. PMID: 35164758; PMCID: PMC8842935.
17. Shang A, Gu C, Wang W, et al. Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-β1 axis. Mol Cancer. 2020; 19:117. doi: 10.1186/s12943-020-01235-0. PMID: 32713345; PMCID: PMC7384220.
18. Jian X, He H, Zhu J, et al. Hsa_circ_001680 affects the proliferation and migration of CRC and mediates its chemoresistance by regulating BMI1 through miR-340. Mol Cancer. 2020; 19:20. doi: 10.1186/s12943-020-1134-8. Erratum in: Mol Cancer. 2024 May 14;23(1):100. doi: 10.1186/s12943-024-02018-7. PMID: 32005118; PMCID: PMC6993513.
19. Chen J, Wu Y, Luo X, et al. Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer. Theranostics. 2021; 11:7507-7526. doi: 10.7150/thno.59546. PMID: 34158864; PMCID: PMC8210600.
20. Hu Y, Song Q, Zhao J, et al. Identification of plasma hsa_circ_0008673 expression as a potential biomarker and tumor regulator of breast cancer. J Clin Lab Anal. 2020; 34: e23393. doi: 10.1002/jcla.23393. Epub 2020 Aug 18. PMID: 32808350; PMCID: PMC7521290.
21. Xu J, Ji L, Liang Y, et al. CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1. Signal Transduct Target Ther. 2020; 5:298. doi: 10.1038/s41392-020-00375-5. PMID: 33361760; PMCID: PMC7762756.
22. Xu J, Wan Z, Tang M, et al. N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling. Mol Cancer. 2020; 19:163. doi: 10.1186/s12943-020-01281-8. PMID: 33222692; PMCID: PMC7681956.
23. Yin WB, Yan MG, Fang X, Guo JJ, Xiong W, Zhang RP. Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection. Clin Chim Acta. 2018; 487:363-368. doi: 10.1016/j.cca.2017.10.011. Epub 2017 Oct 16. PMID: 29045858.
24. Yang W, Yang X, Wang X, et al. Silencing CDR1as enhances the sensitivity of breast cancer cells to drug resistance by acting as a miR-7 sponge to down-regulate REGγ. J Cell Mol Med. 2019; 23:4921-4932. doi: 10.1016/j.cca.2017.10.011. Epub 2017 Oct 16. PMID: 29045858.
25. Ghafouri-Fard S, Khoshbakht T, Hussen BM, Sarfaraz S, Taheri M, Ayatollahi SA . Circ_CDR1as: A circular RNA with roles in the carcinogenesis. Pathol Res Pract. 2022; 236:153968. doi: 10.1016/j.prp.2022.153968. Epub 2022 Jun 1. PMID: 35667198.
26. Ma HB, Yao YN, Yu JJ, Chen XX, Li HF. Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506. Am J Transl Res. 2018; 10:592-604. PMID: 29511454; PMCID: PMC5835825.
27. Rossi M, Inoue S, Walewska R, Knight RA, Dyer MJ, Cohen GM, et al. Caspase cleavage of Itch in chronic lymphocytic leukemia cells. Biochem Biophys Res Commun. 2009; 379:659-64. doi: 10.1016/j.bbrc.2008.11.154. Epub 2008 Dec 13. PMID: 19073138.
28. Huang G, Zhu H, Shi Y, Wu W, Cai H, Chen X. cir-ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/β-catenin pathway. PLoS One. 2015; 10:e0131225. doi: 10.1371/journal.pone.0131225. PMID: 26110611; PMCID: PMC4482251.
29. Wan L, Zhang L, Fan K, Cheng ZX, Sun QC, Wang JJ. Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/β-Catenin Pathway. Biomed Res Int. 2016; 2016:1579490. doi: 10.1155/2016/1579490. Epub 2016 Aug 24. PMID: 27642589; PMCID: PMC5013215.
30. Guo W, Zhang J, Zhang D, Cao S, Li G, Zhang S, et al. Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma. Oncotarget. 2017; 8:48169-48177. doi: 10.18632/oncotarget.18327. PMID: 28636993; PMCID: PMC5564635.
31. Yang C, Yuan W, Yang X, et al. Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression. Mol Cancer. 2018; 17:19. doi: 10.1186/s12943-018-0771-7. PMID: 29386015; PMCID: PMC5793418.
32. Wang M, Chen B, Ru Z, Cong L. CircRNA circ-ITCH suppresses papillary thyroid cancer progression through miR-22-3p/CBL/β-catenin pathway. Biochem Biophys Res Commun. 2018; 504:283-288. doi: 10.1016/j.bbrc.2018.08.175. Epub 2018 Sep 4. PMID: 30190130.
33. Hu H, Wang Y, Qin Z, et al. Regulation of MRP4 Expression by circHIPK3 via Sponging miR-124-3p/miR-4524-5p in Hepatocellular Carcinoma. Biomedicines. 2021; 9:497. doi: 10.3390/biomedicines9050497. PMID: 33946595; PMCID: PMC8147194.
34. Tang Q and Hann SS. Biological Roles and Mechanisms of Circular RNA in Human Cancers. Onco Targets Ther. 2020; 13:2067-2092. doi: 10.2147/OTT.S233672. PMID: 32210574; PMCID: PMC7069569.
35. Huang X, Song C, Zhang J, Zhu L, Tang H. Circular RNAs in breast cancer diagnosis, treatment and prognosis. Oncol Res. 2023;32:241-249. doi: 10.32604/or.2023.046582. PMID: 38186573; PMCID: PMC10765117.
36. Badowski C, He B, Garmire LX. Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty. NPJ Precis Oncol. 2022;6:40. doi: 10.1038/s41698-022-00283-7. PMID: 35729321; PMCID: PMC9213432.
37. Das S, Dey MK, Devireddy R, Gartia MR. Biomarkers in Cancer Detection, Diagnosis, and Prognosis. Sensors (Basel). 2023; 24:37. doi: 10.3390/s24010037. PMID: 38202898; PMCID: PMC10780704.
38. Sang Y, Chen B, Song X, et al. circRNA_0025202 Regulates Tamoxifen Sensitivity and Tumor Progression via Regulating the miR-182-5p/FOXO3a Axis in Breast Cancer. Mol Ther. 2019; 27:1638-1652. doi: 10.1016/j.ymthe.2019.05.011. Epub 2019 May 17. Erratum in: Mol Ther. 2021 Dec 1;29(12):3525-3527. doi: 10.1016/j.ymthe.2021.11.002. PMID: 31153828; PMCID: PMC6731174.
39. Liang HF, Zhang XZ, Liu BG, Jia GT, Li WL. Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Am J Cancer Res. 2017; 7:1566-1576. PMID: 28744405; PMCID: PMC5523036.
40. Zhang J, Xu HD, Xing XJ, Liang ZT, Xia ZH, Zhao Y. CircRNA_069718 promotes cell proliferation and invasion in triple-negative breast cancer by activating Wnt/β-catenin pathway. Eur Rev Med Pharmacol Sci. 2019; 23:5315-5322. doi: 10.26355/eurrev_201906_18198. PMID: 31298383.
41. Chen LL. The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Biol. 2016; 17:205-11. doi: 10.1038/nrm.2015.32. Epub 2016 Feb 24. PMID: 26908011.
42. Tang W, Ji M, He G, et al. Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7. Onco Targets Ther. 2017; 10:2045-2056. PMID: 28435295; PMCID: PMC5391170.
43. Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013; 495:384-8. doi: 10.1038/nature11993. Epub 2013 Feb 27. PMID: 23446346.
44. Clusan L, Ferrière F, Flouriot G, Pakdel F. A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer. Int J Mol Sci. 2023; 24:6834. doi: 10.3390/ijms24076834. PMID: 37047814; PMCID: PMC10095386.
| Files | ||
| Issue | Vol 15 No 4 (2023) | |
| Section | Original Articles | |
| Keywords | ||
| Breast cancer circRNAs Biomarkers Chemotherapy Prognosis | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Mirzaei S, Salimi M, Mozdarani H. CircRNAs as Possible Potential Biomarkers for Breast Cancer Prognosis and Chemotherapy Response: A Comprehensive Study. Basic Clin Cancer Res. 2024;15(4):225-236.
