The Role of microRNA-31 in the Initiation and Progression of Colorectal Cancer
,
Abstract
miR-31 is critically involved in the initiation and progression of CRC by regulating multiple pathways essential for tumorigenesis and influencing various cellular functions, such as proliferation, apoptosis, epithelial-mesenchymal transition (EMT), metastasis, and chemoresistance. miR-31 also impacts EMT-related transcription factors such as ZEB1, SNAIL, and TWIST, which further facilitate the shift to a mesenchymal state, leading to increased invasiveness and metastatic spread of CRC cells, commonly to organs like the liver, which worsens patient prognosis in the context of apoptosis, miR-31 inhibits pro-apoptotic factors such as BAX and Caspase-3, reducing programmed cell death and allowing cancer cells to survive longer this anti-apoptotic influence is essential for miR-31’s role in chemoresistance, as it enables cancer cells to evade the cytotoxic effects of chemotherapy. Interestingly, despite its primarily oncogenic role, miR-31 has shown context-dependent tumor-suppressive properties in specific genetic or environmental conditions under certain conditions, miR-31 may target oncogenes or reduce the activity of tumor-promoting pathways, although these instances are relatively rare and context-specific, influenced by factors like genetic mutations clinically, miR-31’s expression level is correlated with CRC stage, metastatic capacity, and patient prognosis, indicating its potential utility as a biomarker for risk assessment and prognosis. Elevated miR-31 levels are associated with advanced CRC stages, increased tumor aggressiveness, and poor overall survival, underscoring its relevance in patient management ongoing research is investigating miR-31 inhibitors as a therapeutic option to counteract its oncogenic effects and improve treatment responses by sensitizing CRC cells to chemotherapeutic-induced apoptosis.
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2. Kordkatouli M, Sateei A, Mahmood Janlou M A. Roles of miR-21 in the Onset and Advancement of Colorectal Cancer (CRC). Multidiscip Cancer Investig 2024;8(1):0-0
3. Wang Y, Li H, Zhang Y, et al. The role of miR-31 in cancer development and chemoresistance: A review. Oncotarget. 2016;7(14):17040-17056.
4. Li C, Wang H, Zhang J. Investigating the molecular mechanisms of miR-31 in colorectal cancer development. Biomed Pharmacother. 2020;128:110266.
5. Xu Q, Chen W, Yang Y. The effect of miR-31 on tumor immunity in colorectal cancer. Front Immunol. 2020;11:883.
6. Sun X, Wang Y, Li Z. The prognostic significance of miR-31 expression in colorectal cancer: a systematic review and meta-analysis. Cancer Biomark. 2019;26(2):129-138.
7. Liu Z, Zhang Y, Chen L. The role of miR-31 in modulating the tumor microenvironment of colorectal cancer. Cancer Lett. 2021;503:115-123.
8. Fadaka AO, Pretorius A, Klein AJCC. Biomarkers for stratification in colorectal cancer: microRNAs. 2019;26(1):1073274819862784. DOI: 10.1177/1073274819862784
9. Krauß D, Fari O, Sibilia MJM. Lipid Metabolism Interplay in CRC-An Update. 2022;12(3):213. DOI: 10.3390/metabo12030213
10. Li L-B, Wang L-Y, Chen D-M, Liu Y-X, Zhang Y-H, Song W-X, et al. A systematic analysis of the global and regional burden of colon and rectum cancer and the difference between early-and late-onset CRC from 1990 to 2019. 2023;13:1102673. DOI: 10.3389/fonc.2023.1102673
11. Oden K, Nelson M, Williams LJGN. Colonoscopy screening and polyp detection in the Southeastern United States. 2022;45(1):59-62. DOI: 10.1097/SGA.0000000000000591
12. Basnet U, Patil AR, Kulkarni A, Roy SJIJoER, Health P. Role of Stress-Survival Pathways and Transcriptomic Alterations in Progression of Colorectal Cancer: A Health Disparities Perspective. 2021;18(11):5525. DOI: 10.3390/ijerph18115525
13. Ye Y-P, Wu P, Gu C-c, Deng D-l, Jiao H-L, Li T-T, et al. miR-450b-5p induced by oncogenic KRAS is required for colorectal cancer progression. 2016;7(38):61312. DOI: 10.18632/oncotarget.11016
14. Huang T, Lin C, Zhong LL, Zhao L, Zhang G, Lu A, et al. Targeting histone methylation for colorectal cancer. 2017;10(1):114-31. DOI: 10.1177/1756283X16671287
15. Gezici S, Sekeroglu NJc. Regulation of microRNAs by natural products and bioactive compounds obtained from common medicinal plants: novel strategy in cancer therapy. 2017;1(4):71. DOI: 10.5530/ijper.51.3s.71
16. Paczynska P, Grzemski A, Szydlowski MJBg. Distribution of miRNA genes in the pig genome. 2015;16:1-12. DOI: 10.1186/s12863-015-0166-3
17. Zhang D, Hao P, Jin L, Wang Y, Yan Z, Wu SJMMR. MicroRNA 940 promotes cell proliferation and invasion of glioma by directly targeting Kruppel like factor 9. 2019;19(1):734-42. DOI: 10.3892/mmr.2018.9630
18. Carroll AP, Goodall GJ, Liu BJWIRR. Understanding principles of miRNA target recognition and function through integrated biological and bioinformatics approaches. 2014;5(3):361-79. DOI: 10.1002/wrna.1217
19. MacFarlane L-A, R Murphy PJCg. MicroRNA: biogenesis, function and role in cancer. 2010;11(7):537-61. DOI: 10.2174/138920210793175895
20. Louis DN, Perry A, Reifenberger G, Von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. 2016;131:803-20. DOI: 10.1007/s00401-016-1545-1
21. Zhang Y, Liu Z, Wang H. The role of miR-31 in colorectal cancer: potential target for therapy. Cancer Lett. 2020;476:103-110.
22. Chen Z, Chen W, Li Y. miR-31 regulates the invasion and metastasis of colorectal cancer by targeting E-cadherin. Oncol Lett. 2018;16(5):5847-5854.
23. Kim S, Choi Y, Park J. Regulation of the Wnt/β-catenin pathway by miR-31 in colorectal cancer cells. Cancer Sci. 2019;110(8):2582-2591.
24. Huang Y, Wang Y, Chen L. miR-31 promotes colorectal cancer progression by targeting PTEN. Biochem Biophys Res Commun. 2017;486(4):948-953.
25. Li Q, Zhang Y, Yang Y. The role of miR-31 in the regulation of the Ras signaling pathway in colorectal cancer. Exp Mol Med. 2021;53(6):837-849.
26. Jiang H, Liu X, Zhao H. Inhibition of miR-31 enhances sensitivity of colorectal cancer cells to chemotherapy. Cancer Chemother Pharmacol. 2020;86(2):231-239.
27. Wu C, Zhang J, Feng S. miR-31 modulates apoptosis and drug resistance in colorectal cancer. J Exp Clin Cancer Res. 2019;38:33.
28. Yang F, Li C, Xu C. miR-31 is a potential biomarker for predicting prognosis in colorectal cancer patients. Clin Transl Oncol. 2020;22(4):586-593.
29. Liu M, Zhang L, Xu B. The role of miR-31 in epithelial-mesenchymal transition and its clinical significance in colorectal cancer. J Cancer. 2018;9(16):2883-2890.
30. Chen Y, Wang M, Li D. The interaction between miR-31 and its target genes in colorectal cancer. Oncol Lett. 2019;17(3):2582-2589.
31. Sun J, Wang S, Liu T. The clinical significance of miR-31 expression in colorectal cancer. Oncol Rep. 2020;43(1):221-228.
32. Zhang L, Chen X, Yu C. miR-31 promotes colorectal cancer progression by inhibiting the expression of tumor suppressors. J Surg Oncol. 2021;123(4):748-755.
33. Wang T, Zhu W, Chen Y. miR-31 and its role in the regulation of cancer stem cells in colorectal cancer. Cancer Lett. 2020;478:107-115.
34. Zhao M, Wang Y, Zhang L. The regulatory role of miR-31 in the tumor microenvironment of colorectal cancer. J Exp Clin Cancer Res. 2018;37:125.
35. Lee Y, Kim J, Kim Y. The significance of miR-31 in chemoresistance in colorectal cancer: a review. Int J Mol Sci. 2020;21(3):934.
36. Luo X, Wu Q, Yang X. Targeting miR-31 as a novel therapeutic strategy for colorectal cancer. Cancer Lett. 2019;455:49-55.
37. Huang J, Zhou Z, Chen Q. The effect of miR-31 on the proliferation and migration of colorectal cancer cells. Oncol Lett. 2018;16(6):7387-7393.
38. Wang J, Zhang H, Li Y. The involvement of miR-31 in colorectal cancer metastasis and chemoresistance. Clin Exp Metastasis. 2020;37(6):823-831.
39. Feng J, Liu J, Wang L. The relationship between miR-31 expression and prognosis in colorectal cancer: a meta-analysis. Cancer Manag Res. 2019;11:8853-8861.
40. Xu J, He X, Zhao S. Role of miR-31 in regulating apoptosis in colorectal cancer. J Biol Chem. 2021;296:100195.
41. Shen J, Yu X, Li J. Upregulation of miR-31 correlates with poor prognosis in colorectal cancer patients. Mol Clin Oncol. 2020;12(1):123-130.
42. Chen H, Zhang Y, Liu Y. miR-31 regulates drug resistance in colorectal cancer by targeting multiple oncogenes. Cancer Cell Int. 2020;20:212.
43. Wu Q, Lin S, Hu Z. The role of miR-31 in colorectal cancer: implications for diagnosis and therapy. Cancer Biomark. 2019;25(3):321-329.
44. Li Z, Xie X, Chen Q. The impact of miR-31 on cell proliferation and invasion in colorectal cancer. Oncol Lett. 2019;18(6):6341-6350.
45. Yang X, Zhao J, Zhang Z. MiR-31 regulates tumor growth and metastasis in colorectal cancer through targeting of multiple genes. Exp Mol Med. 2021;53(7):1022-1032.
46. Zhang X, Guo Z, Li C. Correlation of miR-31 with clinical outcomes in colorectal cancer patients. J Cancer Res Clin Oncol. 2020;146(9):2311-2321.
47. He Y, Zhang Y, Zhou X. miR-31 as a potential therapeutic target for colorectal cancer. Oncotarget. 2019;10(30):2837-2846.
48. Liu Y, Han D, Wu L. The role of miR-31 in colorectal cancer and its relationship with other microRNAs. J Cancer. 2020;11(4):934-941.
49. Zhao W, Yang Y, Hu Y. The interaction between miR-31 and its target genes in colorectal cancer: a meta-analysis. Cancer Genet. 2021;257:12-20.
50. Wang Y, Zhu L, Li Q. Efficacy of miR-31 inhibitors in enhancing chemosensitivity in colorectal cancer. Int J Clin Exp Pathol. 2020;13(4):817-826.
51. Kordkatouli M, CHO WC, Bondarkhilli SAM, Dulskas A, Qureshi SAM.Oct-4 and Its Role in the Oncogenesis of Colorectal Cancer. Middle East Journal of Cancer. 2024;15: -. https://mejc.sums.ac.ir/article_49918_25eefc8c3eb0cd9d54 3213163f2a0624.pdf
52. Kordkatouli M, Sateei A, Dulskas A. Potential Roles and Mechanisms of Avena Sativa in Cancer Prevention. Multidisciplinary Cancer Investigation. 2024;8(2):0-0.
53. Chen G, Yang S, Li Y. The involvement of miR-31 in colorectal cancer stem cell maintenance. Stem Cell Res Ther. 2019;10:261.
54. Feng Y, Zhao Y, Wang J. miR-31 promotes CRC cell migration and invasion by targeting the negative regulators of EMT. J Cancer. 2021;12(3):751-760.
55. Yang X, Liu T, Zhang X. The impact of inflammation on miR-31 expression in colorectal cancer. Front Oncol. 2020;10:468.
56. Wu S, Xu Y, Wei L. The role of miR-31 in the regulation of apoptotic signaling pathways in colorectal cancer. Cancer Chemother Pharmacol. 2021;87(5):669-679.
57. Liu X, Zhang H, Zhang L. The interplay between miR-31 and the tumor microenvironment in colorectal cancer. Oncol Lett. 2018;16(6):7501-7510.
58. He L, Xu Y, Chen J. The potential of miR-31 as a biomarker for colorectal cancer diagnosis and prognosis. Oncol Lett. 2019;18(5):4736-4746.
59. Gao J, Wang Q, Lu M. miR-31 in the pathogenesis of colorectal cancer: a potential biomarker for therapeutic targeting. Cancer Lett. 2020;485:69-76.
60. Li J, Zeng H, Feng Y. The regulation of cell cycle progression by miR-31 in colorectal cancer. Int J Mol Med. 2019;44(4):1554-1562.
61. Zhang X, Zhang J, Zhao Y. miR-31 is a novel modulator of epithelial-mesenchymal transition in colorectal cancer. Cell Death Dis. 2021;12:45.
62. Liu J, Zhang X, Yang Y. The correlation between miR-31 expression and patient survival in colorectal cancer: a meta-analysis. Cancer Manag Res. 2020;12:11151-11160.
63. Zhao J, Zhang W, Yu S. Inhibition of miR-31 enhances chemosensitivity in colorectal cancer cells. J Biochem. 2020;167(2):135-143.
64. Xu L, Li Y, Chen Z. The relationship between miR-31 expression and clinicopathological features in colorectal cancer. J Cancer. 2021;12(12):3486-3496.
65. Zhang R, Liu Y, Wu Q. The impact of miR-31 on the Wnt/β-catenin signaling pathway in colorectal cancer. Cancer Lett. 2019;465:32-39.
66. Wang H, Wu J, Zhang C. The role of miR-31 in regulating colorectal cancer metastasis and prognosis. J Cancer Res Clin Oncol. 2020;146(1):181-191.
67. Zhao L, Liu Y, Zheng Z, et al. The role of microRNA-31 in colorectal cancer: a comprehensive review. J Cancer Res Clin Oncol. 2020;146(1):1-10.
68. Moloudizargari M, Rahmani J, Asghari MH, Goel A. The prognostic role of miR-31 in colorectal cancer: the results of a meta-analysis of 4720 patients. Epigenomics. 2022 Jan;14(2):101-112.
2. Kordkatouli M, Sateei A, Mahmood Janlou M A. Roles of miR-21 in the Onset and Advancement of Colorectal Cancer (CRC). Multidiscip Cancer Investig 2024;8(1):0-0
3. Wang Y, Li H, Zhang Y, et al. The role of miR-31 in cancer development and chemoresistance: A review. Oncotarget. 2016;7(14):17040-17056.
4. Li C, Wang H, Zhang J. Investigating the molecular mechanisms of miR-31 in colorectal cancer development. Biomed Pharmacother. 2020;128:110266.
5. Xu Q, Chen W, Yang Y. The effect of miR-31 on tumor immunity in colorectal cancer. Front Immunol. 2020;11:883.
6. Sun X, Wang Y, Li Z. The prognostic significance of miR-31 expression in colorectal cancer: a systematic review and meta-analysis. Cancer Biomark. 2019;26(2):129-138.
7. Liu Z, Zhang Y, Chen L. The role of miR-31 in modulating the tumor microenvironment of colorectal cancer. Cancer Lett. 2021;503:115-123.
8. Fadaka AO, Pretorius A, Klein AJCC. Biomarkers for stratification in colorectal cancer: microRNAs. 2019;26(1):1073274819862784. DOI: 10.1177/1073274819862784
9. Krauß D, Fari O, Sibilia MJM. Lipid Metabolism Interplay in CRC-An Update. 2022;12(3):213. DOI: 10.3390/metabo12030213
10. Li L-B, Wang L-Y, Chen D-M, Liu Y-X, Zhang Y-H, Song W-X, et al. A systematic analysis of the global and regional burden of colon and rectum cancer and the difference between early-and late-onset CRC from 1990 to 2019. 2023;13:1102673. DOI: 10.3389/fonc.2023.1102673
11. Oden K, Nelson M, Williams LJGN. Colonoscopy screening and polyp detection in the Southeastern United States. 2022;45(1):59-62. DOI: 10.1097/SGA.0000000000000591
12. Basnet U, Patil AR, Kulkarni A, Roy SJIJoER, Health P. Role of Stress-Survival Pathways and Transcriptomic Alterations in Progression of Colorectal Cancer: A Health Disparities Perspective. 2021;18(11):5525. DOI: 10.3390/ijerph18115525
13. Ye Y-P, Wu P, Gu C-c, Deng D-l, Jiao H-L, Li T-T, et al. miR-450b-5p induced by oncogenic KRAS is required for colorectal cancer progression. 2016;7(38):61312. DOI: 10.18632/oncotarget.11016
14. Huang T, Lin C, Zhong LL, Zhao L, Zhang G, Lu A, et al. Targeting histone methylation for colorectal cancer. 2017;10(1):114-31. DOI: 10.1177/1756283X16671287
15. Gezici S, Sekeroglu NJc. Regulation of microRNAs by natural products and bioactive compounds obtained from common medicinal plants: novel strategy in cancer therapy. 2017;1(4):71. DOI: 10.5530/ijper.51.3s.71
16. Paczynska P, Grzemski A, Szydlowski MJBg. Distribution of miRNA genes in the pig genome. 2015;16:1-12. DOI: 10.1186/s12863-015-0166-3
17. Zhang D, Hao P, Jin L, Wang Y, Yan Z, Wu SJMMR. MicroRNA 940 promotes cell proliferation and invasion of glioma by directly targeting Kruppel like factor 9. 2019;19(1):734-42. DOI: 10.3892/mmr.2018.9630
18. Carroll AP, Goodall GJ, Liu BJWIRR. Understanding principles of miRNA target recognition and function through integrated biological and bioinformatics approaches. 2014;5(3):361-79. DOI: 10.1002/wrna.1217
19. MacFarlane L-A, R Murphy PJCg. MicroRNA: biogenesis, function and role in cancer. 2010;11(7):537-61. DOI: 10.2174/138920210793175895
20. Louis DN, Perry A, Reifenberger G, Von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. 2016;131:803-20. DOI: 10.1007/s00401-016-1545-1
21. Zhang Y, Liu Z, Wang H. The role of miR-31 in colorectal cancer: potential target for therapy. Cancer Lett. 2020;476:103-110.
22. Chen Z, Chen W, Li Y. miR-31 regulates the invasion and metastasis of colorectal cancer by targeting E-cadherin. Oncol Lett. 2018;16(5):5847-5854.
23. Kim S, Choi Y, Park J. Regulation of the Wnt/β-catenin pathway by miR-31 in colorectal cancer cells. Cancer Sci. 2019;110(8):2582-2591.
24. Huang Y, Wang Y, Chen L. miR-31 promotes colorectal cancer progression by targeting PTEN. Biochem Biophys Res Commun. 2017;486(4):948-953.
25. Li Q, Zhang Y, Yang Y. The role of miR-31 in the regulation of the Ras signaling pathway in colorectal cancer. Exp Mol Med. 2021;53(6):837-849.
26. Jiang H, Liu X, Zhao H. Inhibition of miR-31 enhances sensitivity of colorectal cancer cells to chemotherapy. Cancer Chemother Pharmacol. 2020;86(2):231-239.
27. Wu C, Zhang J, Feng S. miR-31 modulates apoptosis and drug resistance in colorectal cancer. J Exp Clin Cancer Res. 2019;38:33.
28. Yang F, Li C, Xu C. miR-31 is a potential biomarker for predicting prognosis in colorectal cancer patients. Clin Transl Oncol. 2020;22(4):586-593.
29. Liu M, Zhang L, Xu B. The role of miR-31 in epithelial-mesenchymal transition and its clinical significance in colorectal cancer. J Cancer. 2018;9(16):2883-2890.
30. Chen Y, Wang M, Li D. The interaction between miR-31 and its target genes in colorectal cancer. Oncol Lett. 2019;17(3):2582-2589.
31. Sun J, Wang S, Liu T. The clinical significance of miR-31 expression in colorectal cancer. Oncol Rep. 2020;43(1):221-228.
32. Zhang L, Chen X, Yu C. miR-31 promotes colorectal cancer progression by inhibiting the expression of tumor suppressors. J Surg Oncol. 2021;123(4):748-755.
33. Wang T, Zhu W, Chen Y. miR-31 and its role in the regulation of cancer stem cells in colorectal cancer. Cancer Lett. 2020;478:107-115.
34. Zhao M, Wang Y, Zhang L. The regulatory role of miR-31 in the tumor microenvironment of colorectal cancer. J Exp Clin Cancer Res. 2018;37:125.
35. Lee Y, Kim J, Kim Y. The significance of miR-31 in chemoresistance in colorectal cancer: a review. Int J Mol Sci. 2020;21(3):934.
36. Luo X, Wu Q, Yang X. Targeting miR-31 as a novel therapeutic strategy for colorectal cancer. Cancer Lett. 2019;455:49-55.
37. Huang J, Zhou Z, Chen Q. The effect of miR-31 on the proliferation and migration of colorectal cancer cells. Oncol Lett. 2018;16(6):7387-7393.
38. Wang J, Zhang H, Li Y. The involvement of miR-31 in colorectal cancer metastasis and chemoresistance. Clin Exp Metastasis. 2020;37(6):823-831.
39. Feng J, Liu J, Wang L. The relationship between miR-31 expression and prognosis in colorectal cancer: a meta-analysis. Cancer Manag Res. 2019;11:8853-8861.
40. Xu J, He X, Zhao S. Role of miR-31 in regulating apoptosis in colorectal cancer. J Biol Chem. 2021;296:100195.
41. Shen J, Yu X, Li J. Upregulation of miR-31 correlates with poor prognosis in colorectal cancer patients. Mol Clin Oncol. 2020;12(1):123-130.
42. Chen H, Zhang Y, Liu Y. miR-31 regulates drug resistance in colorectal cancer by targeting multiple oncogenes. Cancer Cell Int. 2020;20:212.
43. Wu Q, Lin S, Hu Z. The role of miR-31 in colorectal cancer: implications for diagnosis and therapy. Cancer Biomark. 2019;25(3):321-329.
44. Li Z, Xie X, Chen Q. The impact of miR-31 on cell proliferation and invasion in colorectal cancer. Oncol Lett. 2019;18(6):6341-6350.
45. Yang X, Zhao J, Zhang Z. MiR-31 regulates tumor growth and metastasis in colorectal cancer through targeting of multiple genes. Exp Mol Med. 2021;53(7):1022-1032.
46. Zhang X, Guo Z, Li C. Correlation of miR-31 with clinical outcomes in colorectal cancer patients. J Cancer Res Clin Oncol. 2020;146(9):2311-2321.
47. He Y, Zhang Y, Zhou X. miR-31 as a potential therapeutic target for colorectal cancer. Oncotarget. 2019;10(30):2837-2846.
48. Liu Y, Han D, Wu L. The role of miR-31 in colorectal cancer and its relationship with other microRNAs. J Cancer. 2020;11(4):934-941.
49. Zhao W, Yang Y, Hu Y. The interaction between miR-31 and its target genes in colorectal cancer: a meta-analysis. Cancer Genet. 2021;257:12-20.
50. Wang Y, Zhu L, Li Q. Efficacy of miR-31 inhibitors in enhancing chemosensitivity in colorectal cancer. Int J Clin Exp Pathol. 2020;13(4):817-826.
51. Kordkatouli M, CHO WC, Bondarkhilli SAM, Dulskas A, Qureshi SAM.Oct-4 and Its Role in the Oncogenesis of Colorectal Cancer. Middle East Journal of Cancer. 2024;15: -. https://mejc.sums.ac.ir/article_49918_25eefc8c3eb0cd9d54 3213163f2a0624.pdf
52. Kordkatouli M, Sateei A, Dulskas A. Potential Roles and Mechanisms of Avena Sativa in Cancer Prevention. Multidisciplinary Cancer Investigation. 2024;8(2):0-0.
53. Chen G, Yang S, Li Y. The involvement of miR-31 in colorectal cancer stem cell maintenance. Stem Cell Res Ther. 2019;10:261.
54. Feng Y, Zhao Y, Wang J. miR-31 promotes CRC cell migration and invasion by targeting the negative regulators of EMT. J Cancer. 2021;12(3):751-760.
55. Yang X, Liu T, Zhang X. The impact of inflammation on miR-31 expression in colorectal cancer. Front Oncol. 2020;10:468.
56. Wu S, Xu Y, Wei L. The role of miR-31 in the regulation of apoptotic signaling pathways in colorectal cancer. Cancer Chemother Pharmacol. 2021;87(5):669-679.
57. Liu X, Zhang H, Zhang L. The interplay between miR-31 and the tumor microenvironment in colorectal cancer. Oncol Lett. 2018;16(6):7501-7510.
58. He L, Xu Y, Chen J. The potential of miR-31 as a biomarker for colorectal cancer diagnosis and prognosis. Oncol Lett. 2019;18(5):4736-4746.
59. Gao J, Wang Q, Lu M. miR-31 in the pathogenesis of colorectal cancer: a potential biomarker for therapeutic targeting. Cancer Lett. 2020;485:69-76.
60. Li J, Zeng H, Feng Y. The regulation of cell cycle progression by miR-31 in colorectal cancer. Int J Mol Med. 2019;44(4):1554-1562.
61. Zhang X, Zhang J, Zhao Y. miR-31 is a novel modulator of epithelial-mesenchymal transition in colorectal cancer. Cell Death Dis. 2021;12:45.
62. Liu J, Zhang X, Yang Y. The correlation between miR-31 expression and patient survival in colorectal cancer: a meta-analysis. Cancer Manag Res. 2020;12:11151-11160.
63. Zhao J, Zhang W, Yu S. Inhibition of miR-31 enhances chemosensitivity in colorectal cancer cells. J Biochem. 2020;167(2):135-143.
64. Xu L, Li Y, Chen Z. The relationship between miR-31 expression and clinicopathological features in colorectal cancer. J Cancer. 2021;12(12):3486-3496.
65. Zhang R, Liu Y, Wu Q. The impact of miR-31 on the Wnt/β-catenin signaling pathway in colorectal cancer. Cancer Lett. 2019;465:32-39.
66. Wang H, Wu J, Zhang C. The role of miR-31 in regulating colorectal cancer metastasis and prognosis. J Cancer Res Clin Oncol. 2020;146(1):181-191.
67. Zhao L, Liu Y, Zheng Z, et al. The role of microRNA-31 in colorectal cancer: a comprehensive review. J Cancer Res Clin Oncol. 2020;146(1):1-10.
68. Moloudizargari M, Rahmani J, Asghari MH, Goel A. The prognostic role of miR-31 in colorectal cancer: the results of a meta-analysis of 4720 patients. Epigenomics. 2022 Jan;14(2):101-112.
| Files | ||
| Issue | Vol 16 No 1 (2024) | |
| Section | Mini-Reviews | |
| Keywords | ||
| Biogenesis Colorectal Cancer EMT Mir-31 | ||
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How to Cite
1.
Kordkatouli M, Mahmood Janlou MA, Dulskas A, Sateei A. The Role of microRNA-31 in the Initiation and Progression of Colorectal Cancer. Basic Clin Cancer Res. 2025;16(1):10-22.
