Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 16 1 2025 05 03 40 58 Josué Mondragón-Morales Instituto Politécnico Nacional Rogelio Rogel-Alvarado Facultad de Enfermería y Obstetricia Iris Noverón-Figueroa Escuela Superior de Medicina, Instituto Politécnico Nacional Max Morales-Gutiérrez Universidad Westhill 2023 11 03 2025 04 13 Background: In the 21st century, the main cause of death in both sexes worldwide are cardiovascular diseases, in second place are neoplasms. In the case of women, the fourth cause of mortality is breast cancer despite the screening. Objective: Understanding the epigenetic mechanisms associated with cervical cancer progression and metastasis, considering its correlation with poor prognosis. Methods: To prepare the present article, the search was done on platforms PubMed and Google Scholar, the search was carried out using the following medical subject headings (MeSH) in the search engine: “metastatic cervical cancer”, “cervical cancer epigenetics”, “cervical cancer genetics”, “cervical cancer mirnas”, “cervical cancer lncrnas”, “cervical cancer clinical trials” and “metastatic cervical cancer hpv”, in combination with boolean connectors ‘AND’ and ‘OR’. A total of 114 articles were reviewed, published between 1989 and 2022. Results and conclusions: It is essential to understand and know the epigenetic mechanisms associated with the cervical cancer pathogenesis and progression, to create new targeted treatment schemes for metastatic cervical cancer to reduce the mortality rate and increase disease-free survival.  https://bccr.tums.ac.ir/index.php/bccrj/article/view/499