Geographic Variation and Trends in Laryngeal Cancer Incidence in Iran: A Comprehensive Analysis
-
Farimah Asghari
,
Hamideh Rashidian
,
Fereshteh Lotfi
,
Fatemeh Mahdavi Sabet
,
Zahra Faraji
,
Kazem Zendehdel
Abstract
Background and Aims: Laryngeal cancer poses a significant health challenge, particularly in Iran, where it exerts a substantial burden on the healthcare system. This study aimed to comprehensively analyze the geographic variation in laryngeal cancer incidence across Iran, estimate its burden in 2022, and project trends up to 2050. Methods: Our study utilized data from two sources: the Iran National Population-based Cancer Registry (INPCR) for a four-year period (2014-2017) and the GLOBOCAN 2022 study. From the INPCR data, we calculated average age-standardized incidence rates (ASIRs) for each province. Additionally, the GLOBOCAN 2022 study provided estimates of laryngeal cancer incidence and mortality rates for 2022, along with projections for future trends until 2050. Results: Laryngeal cancer displayed significant regional variations within Iran between 2014 and 2017, with Kerman and North Khorasan provinces experiencing the highest incidence rates. Laryngeal cancer incidence increased with age and remained considerably higher in males. In 2022, laryngeal cancer represented 2 % of new cancer cases in Iran, with ASIRs higher than global averages. By 2050, a substantial increase in both incidence and mortality rates is projected, emphasizing the growing burden of laryngeal cancer in Iran. Conclusion: This study highlights the substantial variations in laryngeal cancer incidence across Iranian provinces. Our findings suggest that opium use, in addition to established risk factors like tobacco and alcohol, might contribute to the high incidence rates observed in Iran. Early diagnosis and targeted interventions tailored to regional risk factor prevalence are crucial to address the growing public health burden of laryngeal cancer in Iran.
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16. Rastegari A, Baneshi MR, Hajebi A, Noroozi A, Karamouzian M, Shokoohi M, et al. Population size estimation of people who use illicit drugs and alcohol in Iran (2015-2016). Int J Heal policy Manag. 2023(e)ko ;12.
17. Merz F. United Nations Office on Drugs and Crime: World Drug Report 2017. 2017. . SIRIUS - Zeitschrift für Strateg Anal. 2018(e)ko ;2(1):85–6.
18. Mohebbi E, Hadji M, Rashidian H, Rezaianzadeh A, Marzban M, Haghdoost AA, et al. Opium use and the risk of head and neck squamous cell carcinoma. Int J cancer. 2021(e)ko ;148(5):1066–76.
19. Najafipour H, Masoumi M, Amirzadeh R, Rostamzadeh F, Foad R, Farrokhi MS. Trends in the Prevalence and Incidence of Opium Abuse and its Association with Coronary Artery Risk Factors in Adult Population in Iran: Findings from Kerman Coronary Artery Disease Risk Factors Study. Iran J Med Sci. 2022(e)ko ;47(4):328.
20. Hwang E, Johnson-Obaseki S, McDonald JT, Connell C, Corsten M. Incidence of head and neck cancer and socioeconomic status in Canada from 1992 to 2007. Oral Oncol [Internet]. 2013(e)ko ;49(11):1072–6. Available at: http://dx.doi.org/10.1016/j.oraloncology.2013.08.002
21. Andersen ZJ, Lassen CF, Clemmensen IH. Social inequality and incidence of and survival from cancers of the mouth, pharynx and larynx in a population-based study in Denmark, 1994-2003. Eur J Cancer. 2008(e)ko irailakaren ;44(14):1950–61.
22. Tang JA, Lango MN. Diverging incidence trends for larynx and tonsil cancer in low socioeconomic regions of the US. Oral Oncol [Internet]. 2019(e)ko ;91(March):65–8. Available at: https://doi.org/10.1016/j.oraloncology.2019.02.024
23. Purkayastha M, McMahon AD, Gibson J, Conway DI. Trends of oral cavity, oropharyngeal and laryngeal cancer incidence in Scotland (1975–2012) – A socioeconomic perspective. Oral Oncol [Internet]. 2016(e)ko ;61:70–5. Available at: http://dx.doi.org/10.1016/j.oraloncology.2016.08.015
24. Edwards DM, Jones J. Incidence of and survival from upper aerodigestive tract cancers in the U.K.: the influence of deprivation. Eur J Cancer. 1999(e)ko ekainakaren ;35(6):968–72.
25. Johnson S, McDonald JT, Corsten MJ. Socioeconomic factors in head and neck cancer. J Otolaryngol - head neck Surg = Le J d’oto-rhino-laryngologie Chir cervico-faciale. 2008(e)ko abuztuakaren ;37(4):597–601.
26. Neisi A. A survey on the human development index in the Provinces of Iran. Jundishapur J Heal Sci [Internet]. 2(1):55–62. Available at: https://brieflands.com/articles/jjhs-76945
27. Reza Alizadeh-Navaei, Akbar Hedayatizadeh-Omran, Ghasem Janbabai. Cancer Incidence pattern in Iran Provinces and Association with Human Development Index. World Cancer Res J. 2017(e)ko ;4(3):1–4.
28. Atlas of STEPwise approach to noncommunicable disease (NCD) risk factor surveillance (STEPs) 2021.Spring 2022.
29. Rastegari A, Baneshi MR, Hajebi A, Noroozi A, Karamouzian M, Shokoohi M, et al. Population Size Estimation of People Who Use Illicit Drugs and Alcohol in Iran (2015-2016). Int J Heal Policy Manag. 2023(e)ko ;12(1):1–7.
30. Lechien JR, Sadoughi B, Hans S. Laryngeal cancers in paediatric and young adult patients: epidemiology, biology and treatment. Curr Opin Otolaryngol Head Neck Surg. 2022(e)ko ;30(2):145–53.
31. Gholizadeh N, Najafi S, Zadeh K, Afzali S. Trend in laryngeal cancer , mortality and survival rate in Iran. 2018(e)ko ;7–11.
32. Jackson CR, Shuman AG, Hogikyan ND. A critical review of head and neck cancer screening. Eur J Clin Med Oncol. 2011(e)ko urtarrilakaren 1a;3:33–41.
33. Teppo H, Koivunen P, Hyrynkangas K, Alho O. DIAGNOSTIC DELAYS IN LARYNGEAL CARCINOMA : PROFESSIONAL DIAGNOSTIC DELAY IS A STRONG. 2003(e)ko ;(May):389–94.
34. Gogarty DS, Shuman A, O’sullivan EM, Sheahan P, Kinsella J, Timon C, et al. Conceiving a national head and neck cancer screening programme. J Laryngol Otol. 2016(e)ko ;130(1):8–14.
35. Gholizadeh N, Najafi S, Zadeh MK, Afzali S, Sheykhbahaeid N. Trend in laryngeal cancer, mortality and survival rate in Iran. J Contemp Med Sci. 2018(e)ko ;4(1).
2. Ferlay J, Ervik M, Lam F, Laversanne M, Colombet M, Mery L, Piñeros M, Znaor A, Soerjomataram I BF. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Available from: https://gco.iarc.who.int/today,. 2024.
3. Deng Y, Wang M, Zhou L, Zheng Y, Li N, Tian T, et al. Global burden of larynx cancer , 1990-2017 : estimates from the global burden of disease 2017 study. 2020(e)ko ;12(3):1990–2017.
4. Wang JY, Zhang QW, Wen K, Wang C, Ji X, Zhang L. Temporal trends in incidence and mortality rates of laryngeal cancer at the global, regional and national levels, 1990-2017. BMJ Open. 2021(e)ko ;11(10):1–8.
5. Nocini R, Molteni G, Mattiuzzi C, Lippi G. Updates on larynx cancer epidemiology. Chin J Cancer Res. 2020(e)ko otsailakaren ;32(1):18–25.
6. Saedi B, Razmpa E, Sadeghi M, Mojtahed M, Mojtahed A. The epidemiology of laryngeal cancer in a country on the esophageal cancer belt. Indian J Otolaryngol Head Neck Surg. 2009(e)ko ;61:213–7.
7. Koroulakis A, Agarwal M. Laryngeal cancer. 2018(e)ko ;
8. Alizadeh H, Naghibzadeh-Tahami A, Khanjani N, Yazdi-Feyzabadi V, Eslami H, Borhaninejad V, et al. Opium use and head and neck cancers: a matched case-control study in Iran. Asian Pacific J cancer Prev APJCP. 2020(e)ko ;21(3):783.
9. Fitzmaurice C, Abate D, Abbasi N, Abbastabar H, Abd-Allah F, Abdel-Rahman O, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-Adjusted life-years for 29 cancer groups, 1990 to 2017: A systematic analysis for the global burden of disease study. JAMA Oncol. 2019(e)ko abenduakaren ;5(12):1749–68.
10. Mirzaei M, Hosseini S-A, Ghoncheh M, Soheilipour F, Soltani S, Soheilipour F, et al. Epidemiology and trend of head and neck cancers in Iran. Glob J Health Sci. 2016(e)ko ;8(1):189.
11. Roshandel G, Ferlay J, Ghanbari‐Motlagh A, Partovipour E, Salavati F, Aryan K, et al. Cancer in Iran 2008 to 2025: Recent incidence trends and short‐term predictions of the future burden. Int J cancer. 2021(e)ko ;149(3):594–605.
12. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021(e)ko ;71(3):209–49.
13. Roshandel G, Ghanbari-Motlagh A, Partovipour E, Salavati F, Hasanpour-Heidari S, Mohammadi G, et al. Cancer incidence in Iran in 2014: results of the Iranian National Population-based Cancer Registry. Cancer Epidemiol. 2019(e)ko ;61:50–8.
14. Nemati S, Mohebbi E, Toorang F, Hadji M, Hosseini B, Saeedi E, et al. Population attributable proportion and number of cancer cases attributed to potentially modifiable risk factors in Iran in 2020. Int J Cancer. 2023(e)ko ;153(10):1758–65.
15. Sohrabi MR, Abbasi-Kangevari M, Kolahi AA. Current Tobacco Smoking Prevalence Among Iranian Population: A Closer Look at the STEPS Surveys. Front Public Heal. 2020(e)ko ;8(December):1–8.
16. Rastegari A, Baneshi MR, Hajebi A, Noroozi A, Karamouzian M, Shokoohi M, et al. Population size estimation of people who use illicit drugs and alcohol in Iran (2015-2016). Int J Heal policy Manag. 2023(e)ko ;12.
17. Merz F. United Nations Office on Drugs and Crime: World Drug Report 2017. 2017. . SIRIUS - Zeitschrift für Strateg Anal. 2018(e)ko ;2(1):85–6.
18. Mohebbi E, Hadji M, Rashidian H, Rezaianzadeh A, Marzban M, Haghdoost AA, et al. Opium use and the risk of head and neck squamous cell carcinoma. Int J cancer. 2021(e)ko ;148(5):1066–76.
19. Najafipour H, Masoumi M, Amirzadeh R, Rostamzadeh F, Foad R, Farrokhi MS. Trends in the Prevalence and Incidence of Opium Abuse and its Association with Coronary Artery Risk Factors in Adult Population in Iran: Findings from Kerman Coronary Artery Disease Risk Factors Study. Iran J Med Sci. 2022(e)ko ;47(4):328.
20. Hwang E, Johnson-Obaseki S, McDonald JT, Connell C, Corsten M. Incidence of head and neck cancer and socioeconomic status in Canada from 1992 to 2007. Oral Oncol [Internet]. 2013(e)ko ;49(11):1072–6. Available at: http://dx.doi.org/10.1016/j.oraloncology.2013.08.002
21. Andersen ZJ, Lassen CF, Clemmensen IH. Social inequality and incidence of and survival from cancers of the mouth, pharynx and larynx in a population-based study in Denmark, 1994-2003. Eur J Cancer. 2008(e)ko irailakaren ;44(14):1950–61.
22. Tang JA, Lango MN. Diverging incidence trends for larynx and tonsil cancer in low socioeconomic regions of the US. Oral Oncol [Internet]. 2019(e)ko ;91(March):65–8. Available at: https://doi.org/10.1016/j.oraloncology.2019.02.024
23. Purkayastha M, McMahon AD, Gibson J, Conway DI. Trends of oral cavity, oropharyngeal and laryngeal cancer incidence in Scotland (1975–2012) – A socioeconomic perspective. Oral Oncol [Internet]. 2016(e)ko ;61:70–5. Available at: http://dx.doi.org/10.1016/j.oraloncology.2016.08.015
24. Edwards DM, Jones J. Incidence of and survival from upper aerodigestive tract cancers in the U.K.: the influence of deprivation. Eur J Cancer. 1999(e)ko ekainakaren ;35(6):968–72.
25. Johnson S, McDonald JT, Corsten MJ. Socioeconomic factors in head and neck cancer. J Otolaryngol - head neck Surg = Le J d’oto-rhino-laryngologie Chir cervico-faciale. 2008(e)ko abuztuakaren ;37(4):597–601.
26. Neisi A. A survey on the human development index in the Provinces of Iran. Jundishapur J Heal Sci [Internet]. 2(1):55–62. Available at: https://brieflands.com/articles/jjhs-76945
27. Reza Alizadeh-Navaei, Akbar Hedayatizadeh-Omran, Ghasem Janbabai. Cancer Incidence pattern in Iran Provinces and Association with Human Development Index. World Cancer Res J. 2017(e)ko ;4(3):1–4.
28. Atlas of STEPwise approach to noncommunicable disease (NCD) risk factor surveillance (STEPs) 2021.Spring 2022.
29. Rastegari A, Baneshi MR, Hajebi A, Noroozi A, Karamouzian M, Shokoohi M, et al. Population Size Estimation of People Who Use Illicit Drugs and Alcohol in Iran (2015-2016). Int J Heal Policy Manag. 2023(e)ko ;12(1):1–7.
30. Lechien JR, Sadoughi B, Hans S. Laryngeal cancers in paediatric and young adult patients: epidemiology, biology and treatment. Curr Opin Otolaryngol Head Neck Surg. 2022(e)ko ;30(2):145–53.
31. Gholizadeh N, Najafi S, Zadeh K, Afzali S. Trend in laryngeal cancer , mortality and survival rate in Iran. 2018(e)ko ;7–11.
32. Jackson CR, Shuman AG, Hogikyan ND. A critical review of head and neck cancer screening. Eur J Clin Med Oncol. 2011(e)ko urtarrilakaren 1a;3:33–41.
33. Teppo H, Koivunen P, Hyrynkangas K, Alho O. DIAGNOSTIC DELAYS IN LARYNGEAL CARCINOMA : PROFESSIONAL DIAGNOSTIC DELAY IS A STRONG. 2003(e)ko ;(May):389–94.
34. Gogarty DS, Shuman A, O’sullivan EM, Sheahan P, Kinsella J, Timon C, et al. Conceiving a national head and neck cancer screening programme. J Laryngol Otol. 2016(e)ko ;130(1):8–14.
35. Gholizadeh N, Najafi S, Zadeh MK, Afzali S, Sheykhbahaeid N. Trend in laryngeal cancer, mortality and survival rate in Iran. J Contemp Med Sci. 2018(e)ko ;4(1).
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| Issue | Vol 15 No 4 (2023) | |
| Section | Original Articles | |
| Keywords | ||
| Laryngeal cancer Geographic variation Incidence Mortality Projection Iran | ||
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How to Cite
1.
Asghari F, Rashidian H, Lotfi F, Mahdavi Sabet F, Faraji Z, Zendehdel K. Geographic Variation and Trends in Laryngeal Cancer Incidence in Iran: A Comprehensive Analysis. Basic Clin Cancer Res. 2024;15(4):266-274.
