Case Reports

An Aggressive Triple Negative Breast Cancer With Early But Favorable Brain Metastatic Course

Abstract

Introduction: Breast cancer is the second most common cause of brain metastasis. Although patient prognosis is poor, isolated brain metastasis occasionally can be an option for treatment with curative intent in breast cancer patients.Case Presentation: We report a patient with invasive ductal carcinoma of the breast who developed an isolated right frontal lobe metastasis within 5 months of finishing her breast cancer treatment. Despite aggressive course of primary disease the metastasis was successfully controlled by surgical excision and adjuvant whole brain radiation therapy. The patient is now quiet well and disease free approximately six years after treatment of brain metastasis.Discussion: A small subgroup of brain metastasis with breast primary can have a considerable survival with adequate local treatment.

Vincent T DeVita TSL, Steven A Rosenberg, Ronald A DePinho, Robert A Weinberg. treatment of metastatic cancer. In: McDermott DALLRaMW, editor. Principles & Practice of Oncology 8th ed: Lippincott Williams & wilkins 2008 p. 2461-75.

Stortebecker TP. Metastatic tumors of the brain from a neurosurgical point of view; a followup study of 158 cases. J Neurosurg. 1954 Jan;11(1):84-111.

Kumar S, Leonard RC. Adjuvant hormonal therapy in early breast cancer. Oncology (Williston Park). 2005 Oct;19(11):1425-8, 33; discussion 33- 41, 44-6.

Holland JF. neoplasms of breast. In: Fisher B kC, Osborne R,Margolic editor. Cancer medicine 4ed. philadelphia: Williams & Wilkins; 1997. p. 2366-8.

F. Amouzegar Hashemi MV, M. sardari An Unusual Metastatic Breast Cancer Presentation; Case Report. Iranian Journal Of Radiation Research 2005;3(1):43.

Sneed PK, Suh JH, Goetsch SJ, Sanghavi SN, Chappell R, Buatti JM, et al. A multiinstitutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases. Int J Radiat Oncol Biol Phys. 2002 Jul 1;53(3):519-26.

Agboola O, Benoit B, Cross P, Da Silva V, Esche B, Lesiuk H, et al. Prognostic factors derived from recursive partition analysis (RPA) of Radiation Therapy Oncology Group (RTOG) brain metastases trials applied to surgically resected and irradiated brain metastatic cases. Int J Radiat Oncol Biol Phys. 1998 Aug 1;42(1):155-9.

Amita M, Sudeep G, Rekha W, Yogesh K, Hemant T. Brain metastasis from cervical carcinoma--a case report. MedGenMed. 2005;7(1):26.

Lagerwaard FJ, Levendag PC, Nowak PJ, Eijkenboom WM, Hanssens PE, Schmitz PI. Identification of prognostic factors in patients with brain metastases: a review of 1292 patients. Int J Radiat Oncol Biol Phys. 1999 Mar 1;43(4):795-803.

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IssueVol 3 No 1 (2011) QRcode
SectionCase Reports
Keywords
Breast Cancer Metastasis Brain Radiotherapy
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Amouzegar-Hashemi F, Torkamani M. An Aggressive Triple Negative Breast Cancer With Early But Favorable Brain Metastatic Course. Basic Clin Cancer Res. 1;3(1):60-64.