Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 3 1 2011 02 01 60 64 EN Farnaz Amouzegar-Hashemi Radiation Oncology department, Cancer Institute, Tehran University of Medical science Marzieh Torkamani Radiation Oncology department, Cancer Institute, Tehran University of Medical science 2011 09 06 2011 09 06 Introduction: Breast cancer is the second most common cause of brain metastasis. Although patient prognosis is poor, isolated brain metastasis occasionally can be an option for treatment with curative intent in breast cancer patients. Case Presentation: We report a patient with invasive ductal carcinoma of the breast who developed an isolated right frontal lobe metastasis within 5 months of finishing her breast cancer treatment. Despite aggressive course of primary disease the metastasis was successfully controlled by surgical excision and adjuvant whole brain radiation therapy. The patient is now quiet well and disease free approximately six years after treatment of brain metastasis. Discussion: A small subgroup of brain metastasis with breast primary can have a considerable survival with adequate local treatment. https://bccr.tums.ac.ir/index.php/bccrj/article/view/9 https://bccr.tums.ac.ir/index.php/bccrj/article/download/9/9