The effect of Stem Cells in the Treatment of Leukemia
-
Kimia Shekarian
,
Arash Abdolmaleki
,
Aida Nahumi
,
Asadollah Asadi
,
Hussein A. Ghanimi
,
Deepak Bhattacharya
Abstract
Background: Stem cells play a key role in tissue repair and regeneration due to their self-renewal properties. In recent years, the use of stem cells as an important and valuable treatment method has created a new hope for the treatment of diseases and disorders that were previously difficult to treat. In this review article, the introduction of stem cells and their capabilities for treatment, as well as the sources of stem cells and the use of these sources for the treatment of diseases, including the treatment of leukemia, have been discussed.Material and Methods: Extensive search in Google Scholar and PubMed using keywords related to the article and review of various articles published between 1957 and 2022 about stem cells and the use of these cells to treat diseases. Results: Recently, it has been proven that hematopoietic stem cells can be produced from pluripotent embryonic stem cells, and hematopoietic stem cells can make different blood cells. These findings help medical science in the treatment of various types of blood cancer. Also, during the conducted research, it has been determined that induced pluripotent stem cells(iPSCs) can be used in the treatment of various diseases, including leukemia.NOTCH, Wnt, TGF-B1 signaling pathways play an important role in the proliferation and differentiation of hematopoietic stem cells. Evidence shows that cancer stem cells have a high ability to create tumors. The presence of cancer stem cells has been reported in some patients, including those with acute myeloid leukemia.Also, the results of research conducted in recent years show that the SALL4 gene can be used in the treatment of leukemia.Conclusions: The results of various researches show that treatment with stem cells, including hematopoietic stem cell transplantation, can be a suitable method for treating patients with leukemia.
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14. Bigas A, Espinosa L. The multiple usages of Notch signaling in development, cell differentiation and cancer. Current opinion in cell biology. 2018;55:1-7.
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23. Nabarrete JM, Pereira AZ, Garófolo A, Seber A, Venancio AM, Grecco CES, et al. Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents. einstein (São Paulo). 2021;19.
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25. Hawsawi YM, Al-Zahrani F, Mavromatis C, Baghdadi MA, Saggu S, Oyouni AAA. Stem cell applications for treatment of cancer and autoimmune diseases: its promises, obstacles, and future perspectives. Technology in cancer research & treatment. 2018;17:1533033818806910.
26. Hammami MB, Talkin R, Al-Taee AM, Schoen MW, Goyal SD, Lai J-P. Autologous graft-versus-host disease of the gastrointestinal tract in patients with multiple myeloma and hematopoietic stem cell transplantation. Gastroenterology Research. 2018;11(1):52.
27. Shimoni A, Hardan I, Shem-Tov N, Yeshurun M, Yerushalmi R, Avigdor A, et al. Allogeneic hematopoietic stem-cell transplantation in AML and MDS using myeloablative versus reduced-intensity conditioning: the role of dose intensity. Leukemia. 2006;20(2):322-8.
28. Santoro N, Ruggeri A, Labopin M, Bacigalupo A, Ciceri F, Gülbaş Z, et al. Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT. Journal of hematology & oncology. 2017;10:1-11.
2. Hoang DM, Pham PT, Bach TQ, Ngo AT, Nguyen QT, Phan TT, et al. Stem cell-based therapy for human diseases. Signal Transduction and Targeted Therapy. 2022;7(1):272.
3. Zakrzewski W, Dobrzyński M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem cell research & therapy. 2019;10:1-22.
4. Larijani B, NASLI EE, Amini P, Nikbin B, Alimoghaddam K, Amiri S, et al. Stem cell therapy in treatment of different diseases. 2012.
5. Biehl JK, Russell B. Introduction to stem cell therapy. The Journal of cardiovascular nursing. 2009;24(2):98.
6. Brianna APK, Ling YP. Applying stem cell therapy in intractable diseases: a narrative review of decades of progress and challenges. Stem Cell Investigation. 2022;9.
7. Nahumi A, Pirdel L, Asadi A, Abdolmaleki A. Evaluation of NLR Family CARD Domain Containing 3 and NLR Family CARD Domain Containing 5 Gene Expression in Interferon Gamma–Treated Mesenchymal Stem Cells from Wharton’s Jelly of Human Umbilical Cord. Gene, Cell and Tissue. 2022;9(2).
8. Han Y, Yang J, Fang J, Zhou Y, Candi E, Wang J, et al. The secretion profile of mesenchymal stem cells and potential applications in treating human diseases. Signal Transduction and Targeted Therapy. 2022;7(1):92.
9. Zaker F, Nasiri N, Oodi A, Amirizadeh N. Evaluation of umbilical cord blood CD34+ hematopoietic stem cell expansion in co-culture with bone marrow mesenchymal stem cells in the presence of TEPA. Hematology. 2013;18(1):39-45.
10. Cibelli JB, Kiessling AA, Cunniff K, Richards C, Lanza RP, West MD. Rapid communication: somatic cell nuclear transfer in humans: pronuclear and early embryonic development. E-biomed: The journal of regenerative medicine. 2001;2(5):25-31.
11. Mehat MS, Sundaram V, Ripamonti C, Robson AG, Smith AJ, Borooah S, et al. Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells in macular degeneration. Ophthalmology. 2018;125(11):1765-75.
12. Saleh M, Shams Asanjan K, Movassaghpour Akbari A, Akbarzadeh P, Molaeipour Z. The Effect of Mesenchymal Stem Cells on Hematopoetic Stem Cells Differentiation. Scientific Journal of Iran Blood Transfus Organ. 2015;12(3):292-302.
13. Kim W, Barron DA, San Martin R, Chan KS, Tran LL, Yang F, et al. RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation. Proceedings of the National Academy of Sciences. 2014;111(46):16389-94.
14. Bigas A, Espinosa L. The multiple usages of Notch signaling in development, cell differentiation and cancer. Current opinion in cell biology. 2018;55:1-7.
15. Moradi S, Baharvand H. Induced pluripotent stem cells, from generation to application. Tehran University Medical Journal TUMS Publications. 2014;72(8):497-507.
16. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. cell. 2006;126(4):663-76.
17. Baharvand H, Totonchi M, Taei A, Seifinejad A, Aghdami N, Salekdeh GH. Human-induced pluripotent stem cells: derivation, propagation, and freezing in serum-and feeder layer-free culture conditions. Human Embryonic Stem Cell Protocols. 2010:425-43.
18. Ghaffari S, Yaghmaie M, Alimoghaddam K, Ghavamzadeh A, Jahani M, Mousavi S, et al. BCR-ABL fusion transcript detection in Iranianpatients with chronic myeloid leukemia. Scientific Journal of Iran Blood Transfus Organ. 2008;5(2):109-16.
19. Ghari M, Fathi E, Farahzadi R. The role of Wnt/β-catenin signaling pathway in blood leukemias. Scientific Journal of Iran Blood Transfus Organ. 2018;15(2):149-64.
20. Kuruca SE, Çelik DD, Özerkan D, Erdemir G. Characterization and isolation of very small embryonic-like (VSEL) stem cells obtained from various human hematopoietic cell sources. Stem Cell Reviews and Reports. 2019;15:730-42.
21. Talleur AC, Flerlage JE, Shook DR, Chilsen AM, Hudson MM, Cheng C, et al. Autologous hematopoietic cell transplantation for the treatment of relapsed/refractory pediatric, adolescent, and young adult Hodgkin lymphoma: a single institutional experience. Bone Marrow Transplantation. 2020;55(7):1357-66.
22. Thomas ED, Lochte Jr HL, Lu WC, Ferrebee JW. Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. New England Journal of Medicine. 1957;257(11):491-6.
23. Nabarrete JM, Pereira AZ, Garófolo A, Seber A, Venancio AM, Grecco CES, et al. Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents. einstein (São Paulo). 2021;19.
24. Gyurkocza B, Rezvani A, Storb RF. Allogeneic hematopoietic cell transplantation: the state of the art. Expert review of hematology. 2010;3(3):285-99.
25. Hawsawi YM, Al-Zahrani F, Mavromatis C, Baghdadi MA, Saggu S, Oyouni AAA. Stem cell applications for treatment of cancer and autoimmune diseases: its promises, obstacles, and future perspectives. Technology in cancer research & treatment. 2018;17:1533033818806910.
26. Hammami MB, Talkin R, Al-Taee AM, Schoen MW, Goyal SD, Lai J-P. Autologous graft-versus-host disease of the gastrointestinal tract in patients with multiple myeloma and hematopoietic stem cell transplantation. Gastroenterology Research. 2018;11(1):52.
27. Shimoni A, Hardan I, Shem-Tov N, Yeshurun M, Yerushalmi R, Avigdor A, et al. Allogeneic hematopoietic stem-cell transplantation in AML and MDS using myeloablative versus reduced-intensity conditioning: the role of dose intensity. Leukemia. 2006;20(2):322-8.
28. Santoro N, Ruggeri A, Labopin M, Bacigalupo A, Ciceri F, Gülbaş Z, et al. Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT. Journal of hematology & oncology. 2017;10:1-11.
| Files | ||
| Issue | Vol 15 No 1 (2023) | |
| Section | Reviews | |
| Keywords | ||
| : stem cell, leukemia, Hematopoietic stem cells (HSCs), induced pluripotent stem cells (iPSCs), differentiation | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Shekarian K, Abdolmaleki A, Nahumi A, Asadi A, Ghanimi HA, Bhattacharya D. The effect of Stem Cells in the Treatment of Leukemia. Basic Clin Cancer Res. 2024;15(1):9-17.
