ASKIN’S TUMOR: A CASE REPORT AND LITERATURE REVIEW
,
Abstract
Askin tumour is an uncommon form of malignant neoplasm that develops from the soft tissues of the thoracopulmonary wall and has neuroectodermal origin and possessing an aggressive behavior. As it mimics other common pediatric disorders such as empyema, tuberculosis, lymphoma, rhabdomyosarcoma and neuroblastoma, it acts as a great diagnostic and therapeutic challenge to the treating clinicians. Its rarity, however, contributes greatly to the absence of standardized treatment protocols further facilitating detrimental prognosis. So, the major deciding factor of its survival rate is early and precise diagnosis followed by its treatment. The present study reports a case Askin’s tumor of child which is locally aggressive and quite rare. While making the definitive diagnosis of an Askin’s tumour of thorcopulmonary region the possibility of occurrence of other primitive neuroectodermal tumors (PNET) was not ruled out.
REFRENCES:
1. Shrestha B, Kapur BN, Karmacharya K, et.al.A Dual Case Study. Int J Pediatr. 2011;2011:252196.
2. Hari S, Jain TP, Thulkar S, et.al. Imaging features of peripheral primitive neuroectodermal tumors. Br J Radiol 2008; 8l (972): 975–83.
3. Contesso G, Llombart-Bosch A, Terrier P et al. Does malignant small round cell tumor of the thoracopulmonary region (Askin tumor) constitute a clinicopathologic entity? An analysis of 30 cases with immunohistochemical and electron-microscopic support treated at the institute Gustave Roussy. Cancer 1992; 69: 1012–20.
4. Xu Q, Xu K, Yang C, et. al. Askin tumor: Four case reports and a review of the literature. Cancer Imaging. 2011; 11(1):184-8.
5. Abbas AA, Almaghraby HQ. The AskinRosai Tumor: A Clinicopathological Review. Clin Surg. 2020; 5: 2914.
6. Vural C, Uluo_glu O, Akyu¨rek N, O_guz A, et. al . The evaluation of CD99 immunoreactivity and EWS/FLI1 translocation by fluorescence in situ hybridization in central PNETs and Ewing’s sarcoma family of tumors. Pathol Oncol Res 2011;17:619e25.
7. Marec-Be´rard P, Chotel F, Claude L. PNET/Ewing tumours: current treatments and future perspectives. Bull Cancer 2010; 97:707e13.
8. Triarico, S., Attinà, G., Maurizi, P. et al. Multimodal treatment of pediatric patients with Askin’s tumors: our experience. World J Surg Onc 16, 140 (2018).
9. Lonergan GJ, Schwab CM, Suarez ES, et. al. Neuroblastoma, ganglioneuroblastoma and ganglioneuroma: Radiologic-pathologic correlation. Radiographics. 2002;22(4):911–34.
10. Jin SG, Jiang XP, Zhong L. Congenital Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor: A Case Report and Review of the Literature. Pediatr Neonatol. 2016 Oct; 57(5):436-439.
11. Mane S S, Prabhudesai A A. Primitive Neuroectodermal Tumor in Infancy - An Unusual Clinical Presentation. Pediatr Oncall J. 2018; 15: 43-45.
12. Badiu T I, Samașca G, Aldea C, et. al. Ganglioneuroblastoma in children. Neurol Sci. 2019 Sep;40(9):1985-1989.
13. Chiloeches FC, Feito RM, Rodríguez BA, et.al. Metastatic neuroblastoma mimicking an infantile hemangioma. Pediatr Dermatol. 2021 Jan;38 (1):316-317.
14. Azizoglu M, Demirsoy U, Kulac I et. al. EWSR1 (22q12) Translocation Positive Pediatric Adrenal Tumor with Loss of 1p, 11q, and Unbalanced Gain of 17q: Neuroblastoma or Ewing Sarcoma? Fetal Pediatr Pathol. 2021 Dec;40(6):717-722.
15. Keka-SA, Ramosaj A, Baloku A, et .al. Peripheral primitive neuroectodermal tumor: a case report. J Med Case Rep. 2022 Mar 31;16(1):128.
16. Keehn B, Jorgensen SA, Towbin AJ, et. al. Askin tumor. Appl Radiol. 2017;46(6):32-33.
17. Sawin RS, Conrad EU, Park JR, et al. Preresection chemotherapy improves survival for children with Askin tumors. Arch Surg. 1996 Aug;131(8):877-80.
18. Veronesi U, Bonadonna G, Zurrida S, et. al. Conservation surgery after primary chemotherapy in large carcinomas of the breast. Ann Surg. 1995 Nov;222(5):612-8.
1. Shrestha B, Kapur BN, Karmacharya K, et.al.A Dual Case Study. Int J Pediatr. 2011;2011:252196.
2. Hari S, Jain TP, Thulkar S, et.al. Imaging features of peripheral primitive neuroectodermal tumors. Br J Radiol 2008; 8l (972): 975–83.
3. Contesso G, Llombart-Bosch A, Terrier P et al. Does malignant small round cell tumor of the thoracopulmonary region (Askin tumor) constitute a clinicopathologic entity? An analysis of 30 cases with immunohistochemical and electron-microscopic support treated at the institute Gustave Roussy. Cancer 1992; 69: 1012–20.
4. Xu Q, Xu K, Yang C, et. al. Askin tumor: Four case reports and a review of the literature. Cancer Imaging. 2011; 11(1):184-8.
5. Abbas AA, Almaghraby HQ. The AskinRosai Tumor: A Clinicopathological Review. Clin Surg. 2020; 5: 2914.
6. Vural C, Uluo_glu O, Akyu¨rek N, O_guz A, et. al . The evaluation of CD99 immunoreactivity and EWS/FLI1 translocation by fluorescence in situ hybridization in central PNETs and Ewing’s sarcoma family of tumors. Pathol Oncol Res 2011;17:619e25.
7. Marec-Be´rard P, Chotel F, Claude L. PNET/Ewing tumours: current treatments and future perspectives. Bull Cancer 2010; 97:707e13.
8. Triarico, S., Attinà, G., Maurizi, P. et al. Multimodal treatment of pediatric patients with Askin’s tumors: our experience. World J Surg Onc 16, 140 (2018).
9. Lonergan GJ, Schwab CM, Suarez ES, et. al. Neuroblastoma, ganglioneuroblastoma and ganglioneuroma: Radiologic-pathologic correlation. Radiographics. 2002;22(4):911–34.
10. Jin SG, Jiang XP, Zhong L. Congenital Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor: A Case Report and Review of the Literature. Pediatr Neonatol. 2016 Oct; 57(5):436-439.
11. Mane S S, Prabhudesai A A. Primitive Neuroectodermal Tumor in Infancy - An Unusual Clinical Presentation. Pediatr Oncall J. 2018; 15: 43-45.
12. Badiu T I, Samașca G, Aldea C, et. al. Ganglioneuroblastoma in children. Neurol Sci. 2019 Sep;40(9):1985-1989.
13. Chiloeches FC, Feito RM, Rodríguez BA, et.al. Metastatic neuroblastoma mimicking an infantile hemangioma. Pediatr Dermatol. 2021 Jan;38 (1):316-317.
14. Azizoglu M, Demirsoy U, Kulac I et. al. EWSR1 (22q12) Translocation Positive Pediatric Adrenal Tumor with Loss of 1p, 11q, and Unbalanced Gain of 17q: Neuroblastoma or Ewing Sarcoma? Fetal Pediatr Pathol. 2021 Dec;40(6):717-722.
15. Keka-SA, Ramosaj A, Baloku A, et .al. Peripheral primitive neuroectodermal tumor: a case report. J Med Case Rep. 2022 Mar 31;16(1):128.
16. Keehn B, Jorgensen SA, Towbin AJ, et. al. Askin tumor. Appl Radiol. 2017;46(6):32-33.
17. Sawin RS, Conrad EU, Park JR, et al. Preresection chemotherapy improves survival for children with Askin tumors. Arch Surg. 1996 Aug;131(8):877-80.
18. Veronesi U, Bonadonna G, Zurrida S, et. al. Conservation surgery after primary chemotherapy in large carcinomas of the breast. Ann Surg. 1995 Nov;222(5):612-8.
| Files | ||
| Issue | Vol 14 No 1 (2022) | |
| Section | Case Reports | |
| DOI | https://doi.org/10.18502/bccr.v14i1.14386 | |
| Keywords | ||
| Askin tumor Neuroectodermal tumors Lung biopsy | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Bhaisare DK, Tellis DJ, Toshniwal DP. ASKIN’S TUMOR: A CASE REPORT AND LITERATURE REVIEW. Basic Clin Cancer Res. 2023;14(1):37-43.
