Original Articles

Cancer has an independent association with death in hospitalized patients with COVID-19: a single-center study in Iran


Background: COVID-19 could cause severe complications in those with pre-existing conditions such as cancer. Here, we aimed to assess the outcome of COVID-19 in hospitalized patients with a history of cancer. Methods: In this retrospective cohort study, we extracted patients' records with any cancer history out of hospitalized patients with COVID-19. Our patients were admitted between February 20th up to July 15th. The primary outcome was death, and the secondary outcomes were overall survival, COVID-19 specific mortality, admission to intensive care unit (ICU) and hospital stay. A group of individuals was selected out of the COVID-19 cohort without cancer history and matched for age, gender, and pre-existing conditions. We utilized univariate and multivariate logistic regression to analyze the association of studied variables and primary outcomes. Results: We identified 46 patients with cancer and COVID-19. The median age was 63, and 54.3% were male. According to the univariate logistic regression analysis, the death was 5.3 (CI95%: 1.75-15.85) times more probable in the cancer patients versus controls (p=0.003). The multivariate analysis adjusted for having cancer and sex, age, and having any comorbidity showed this figure was 5.5 (CI95%:1.8-16.8) (p=0.003). The 30- and 90-day COVID-19 specific mortality was 30% (CI95%:17-43) and 33% (CI95%: 20-46), respectively. Conclusion: Patients with COVID-19 who have a history of cancer have a considerably higher risk of death irrespective of age, gender, and other pre-existing conditions. A group of cancer patients needs the most vigorous care, those with advanced cancers and concurrent bacterial infections.
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IssueVol 13 No 1 (2021) QRcode
SectionOriginal Articles
Iran Cancer COVID-19 SARS-CoV-2 epidemic chemotherapy

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Ghaletaki R, Kolahdouzan K, Rezaei S, Bagheri F, Jafari F, Chavoshi M, Mohammadi N, Seyyedsalehi MS, Nahvijou A, Mousavi Darzikolaee N, Salarvand S, Kazemian A, Aghili M, Zendehdel K. Cancer has an independent association with death in hospitalized patients with COVID-19: a single-center study in Iran. Basic Clin Cancer Res. 2021;13(1):1-8.