Cushing syndrome in a 55-year-old case of small-cell lung cancer
Abstract
Lung cancer is the deadliest type of cancer in the world, and small cell lung cancer (SCLC) is one of the most fatal types of relevant tumors. The aim of this report was to describe the status of a patient presenting with progressive weakness, who did not have a previous medical history. Clinical examination revealed bilateral edema of the lower limbs. Lab results exhibited severe hypokalemia and metabolic alkalosis. physical examination showed elevated blood pressure. Imaging revealed a large mass with necrosis. Bronchoscopy was done and biopsy pathology showed SCLC. The patient underwent chemotherapy with cisplatin and etoposide. Following SCLC, the patient developed a type of paraneoplastic syndrome called Cushing syndrome. He experienced a severe decrease in saturation in the second session of chemotherapy and eventually died. With respect to the fact that most paraneoplastic syndromes are associated with poor response to treatment, high clinical suspicion is essential for the rapid diagnosis of these syndromes to improve outcomes.
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2. Soomro Z, Youssef M, Yust-Katz S, Jalali A, Patel AJ, Mandel J. Paraneoplastic syndromes in small cell lung cancer. Journal of Thoracic Disease. 2020 Oct;12(10):6253.
3. Richa CG, Saad KJ, Halabi GH, Gharios EM, Nasr FL, Merheb MT. Case-series of paraneoplastic Cushing syndrome in small-cell lung cancer. Endocrinology, Diabetes & Metabolism Case Reports. 2018 Mar 8;2018(1).
4. Pingle SR, Shah T, Mosleh W, Kim AS. Cushing syndrome cardiomyopathy: an unusual manifestation of small‐cell lung cancer. ESC Heart Failure. 2020 Oct;7(5):3189-92.
5. Zhang HY, Zhao J. Ectopic C ushing syndrome in small cell lung cancer: A case report and literature review. Thoracic Cancer. 2017 Mar;8(2):114-7.
6. Suyama K, Naito Y, Yoh K, Niho S, Goto K, Ohmatsu H, Nishiwaki Y, Ohe Y. Development of Cushing's syndrome during effective chemotherapy for small cell lung cancer. Internal Medicine. 2011;50(4):335-8.
7. Schmidt S, Werner C, Kloos C, Yomade O, Gabriela SK, Hochhaus A, Wolf G. Case report: Ectopic Cushing syndrome as paraneoplastic manifestation of an advanced small cell lung cancer. InEndocrine Abstracts 2020 Aug 21 (Vol. 70). Bioscientifica.
8. Flombaum CD. Metabolic emergencies in the cancer patient. In Seminars in oncology 2000: 27 (3):322-334.
9. Pandey M, Jha K. Immunology of lung cancer. World Journal of Pathology. 2012 ;1(16).
10. Yeung SC, Habra MA, Thosani SN. Lung cancer-induced paraneoplastic syndromes. Current opinion in pulmonary medicine. 2011;17(4):260-8.
| Files | ||
| Issue | Vol 14 No 3 (2022) | |
| Section | Case Reports | |
| DOI | https://doi.org/10.18502/bccr.v14i3.14352 | |
| Keywords | ||
| Small Cell Lung Cancer; Paraneoplastic; Cushing Syndrome | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Naseri M, Hashem Asnaashari AM, Sorouri S. Cushing syndrome in a 55-year-old case of small-cell lung cancer. Basic Clin Cancer Res. 2023;14(3):151-154.
