Original Articles

The Evaluation Of rs11776042 Polymorphism Effect On Colorectal Cancer Risk In The Iranian Population: A Case-Control Study

Evaluation of rs11776042 In piR-015551 Effect On CRC Risk

Abstract

Background: Recently, it has been shown that, piRNAs as a new class of non-coding RNAs (ncRNAs), play crucial roles in germline development and carcinogenesis. Despite this, the study on the effects of piRNAs polymorphism (piR-SNP) on colorectal cancer (CRC) risk is scarce. We evaluate the impact of rs11776042 in piRNA 015551 on CRC initiation and development in the Iranian population. Matherials & METHODS: The association of novel polymorphisms rs11776042 in piRNA 015551 gene with CRC risk using a case-control study on the Iranian population was estimated. All subjects were evaluated by TETRA primer-Amplification refractory mutation system polymerase chain reaction (TP-ARMS- PCR assay) Results: The genotypes frequency was 27%, 68% and 0.05% for C/C, C/T and T/T in controls and 31%, 65% and 0.04% in CRC patients respectively. The frequency of the C allele was 63% in patients versus 61% in controls and, T allele frequency was 37% in patients versus 39% in controls. Conclusion: No significant difference was found in genotype and allele frequencies between the cases and controls for rs11776042 polymorphism in piRNA 015551 in our population.  
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86 .Law PT, Qin H, Ching AK, et al. Deep sequencing of small RNA transcriptome reveals novel non-coding RNAs in hepatocellular carcinoma. J Hepatol. 2013;58:1165-1173.

87 .Circulating PIWI-Interacting RNAs piR-5937 and piR-28876 Are Promising Diagnostic Biomarkers of Colon Cancer Petra Vychytilova-Faltejskova1,2, Karolina Stitkovcova1 , Lenka Radova1 , Milana Sachlova2 , Zdenka Kosarova1 , Katerina Slaba1 , Zdenek Kala1,3, Marek Svoboda1,2, Igor Kiss2 , Rostislav Vyzula2 , William C. Cho4 , and Ondrej Slaby1,2.

88 .Haiyan Chu PhD, Liping Xia PhD, Xiaonan Qiu MS, Dongying Gu PhD, Linjun Zhu PhD, Jing Jin MS, Gaoyun Hui MS, Qiuhan Hua MS, Mulong Du MS, Na Tong MD, Jinfei Chen PhD, Zhengdong Zhang PhD, Meilin Wang PhD
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SectionOriginal Articles
Keywords
Colorectal Neoplasm (Colorectal Cancer) piR-SNPs rs 11776042 piR_01555

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1.
Mobaraki M, Angaji SA, Nazemalhosseini-Mojarad E, Arbabian S, Asadzadeh Aghdaei H. The Evaluation Of rs11776042 Polymorphism Effect On Colorectal Cancer Risk In The Iranian Population: A Case-Control Study. Basic Clin Cancer Res. 2022;13(3):175-186.