The Evaluation Of rs11776042 Polymorphism Effect On Colorectal Cancer Risk In The Iranian Population: A Case-Control Study
Evaluation of rs11776042 In piR-015551 Effect On CRC Risk
-
Marzieh Mobaraki
,
Hamid Asadzadeh Aghdaei
,
Seyed Abdolhamid Angaji
,
Ehsan Nazemalhosseini-Mojarad
,
Sedigheh Arbabian
Abstract
Background: Recently, it has been shown that, piRNAs as a new class of non-coding RNAs (ncRNAs), play crucial roles in germline development and carcinogenesis. Despite this, the study on the effects of piRNAs polymorphism (piR-SNP) on colorectal cancer (CRC) risk is scarce. We evaluate the impact of rs11776042 in piRNA 015551 on CRC initiation and development in the Iranian population. Matherials & METHODS: The association of novel polymorphisms rs11776042 in piRNA 015551 gene with CRC risk using a case-control study on the Iranian population was estimated. All subjects were evaluated by TETRA primer-Amplification refractory mutation system polymerase chain reaction (TP-ARMS- PCR assay) Results: The genotypes frequency was 27%, 68% and 0.05% for C/C, C/T and T/T in controls and 31%, 65% and 0.04% in CRC patients respectively. The frequency of the C allele was 63% in patients versus 61% in controls and, T allele frequency was 37% in patients versus 39% in controls. Conclusion: No significant difference was found in genotype and allele frequencies between the cases and controls for rs11776042 polymorphism in piRNA 015551 in our population.
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| Issue | Vol 13 No 3 (2021) | |
| Section | Original Articles | |
| DOI | https://doi.org/10.18502/bccr.v13i3.11404 | |
| Keywords | ||
| Colorectal Neoplasm (Colorectal Cancer) piR-SNPs rs 11776042 piR_01555 | ||
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1.
Mobaraki M, Asadzadeh Aghdaei H, Angaji SA, Nazemalhosseini-Mojarad E, Arbabian S. The Evaluation Of rs11776042 Polymorphism Effect On Colorectal Cancer Risk In The Iranian Population: A Case-Control Study. Basic Clin Cancer Res. 2022;13(3):175-186.
