Case Reports

Chronic myeloid leukemia in a young man with unusual presentation of weight loss with bone and abdominal pain


Chronic myeloid leukemia (CML) is a clonal myelo-proliferative neoplasm and one of the main subtypes of leukemia which mainly affects adults. The incidence increases slowly with age until the middle of the fourth decade, then it rises rapidly. Anemia, splenomegaly and constitutional symptoms are the most common signs and symptoms at presentation. Here we report a 27-year-old man who was presented with bone pain and generalized abdominal pain. He also had weight loss, because of anorexia and easy satiety. Qualitative probe based real-time PCR (qRT-PCR) test result was positive for BCR-ABL1 (t9:22) P210 mutation. The patient was treated with imatinib, standard first-line therapy, and showed clinical improvement. His pain was also decreased and discharged in good condition.
1.Lyengar V, Shimanovsky A (2020): Leukemia. Treasure Island (FL): StatPearls Publishing; 2020: Jan.
2. Davis AS, Viera AJ, Mead MD (2014): Leukemia: An overview for primary care. Am Fam Physician;89(9):731–738.
3. Jabbour E, Kantarjian H (2020): Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring. Am J Hematol;95(6):691–709.
4. Deininger MW, Shah NP, Altman JK, Berman E, Bhatia R, et al. (2020): Chronic myeloid leukemia,version 2.2021: NCCN Clinical practice guidelines in oncology. J NatlComprCancNetw;16:1108–35.
5. Algahtani FH, Alqahtany FS (2020): Evaluation and characterisation of chronicmyeloid leukemia and various treatments in Saudi Arabia: A retrospective study. J Infect Public Health;13(2):295–8.
6. Islamiah A, Wardhani SO (2017): A 44-year-oldman with chronic myeloid leukemia and mass at right lower leg. JurnalKedokteranBrawijaya; 29(4):383–6.
7. Kumar L, Baid BL, Singh Y, Kochupillai V (1991): Bone lesions in chronic granulocytic leukaemia.Postgrad Med J;67(790):778.
8. Kantarjian HM, Cortes J, Guilhot F, Hochhaus A, Baccarani M, Lokey L (2007): Diagnosis and management of chronic myeloid leukemia. Cancer; 109: 1365–1375.
9. von Bubnoff N, Duyster J (2010): Chronic myelogenous leukemia: treatment and monitoring. DtschArzteblInt;107(7):114-121.
10. Wei G, Rafiyath S, Liu D (2010): First-line treatment for chronic myeloid leukemia: dasatinib, nilotinib, or Imatinib. J HematolOncol;3:47. 1
IssueVol 13 No 1 (2021) QRcode
SectionCase Reports
Chronic Myeloid Leukemia CML Bone pain Weight loss

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How to Cite
Mohamadian N, Seyedmoradi M, Izadi B, Amirian F, Ramezani M. Chronic myeloid leukemia in a young man with unusual presentation of weight loss with bone and abdominal pain. Basic Clin Cancer Res. 2022;13(1):51-54.