Head & Neck Interdigitating Dendritic Cell Sarcoma: A Case Report & Literature Review
Abstract
Interdigitating dendritic cells (IDCs) act as antigen-presenting cells (APC) of the immune system and have the ability to stimulate T cells. These cells are mostly seen in the paracortex of the lymph node. The interdigitating dendritic cell sarcoma (IDCS) originating from the IDC is an extremely rare tumor. This tumor is observed in both lymph nodes and non-lymph nodes. This malignancy is difficult to diagnose due to its rarity, and thus far no guideline has been established for its treatment. However, it seems that the best treatment for this malignancy is radical resection of the tumor. Meanwhile, the role of chemotherapy and radiotherapy in the survival and recurrence of the tumor is not clear. In this study, we present a case of IDCS originating from a cervical lymph node, which was first exposed to mass resection, with IHC evaluation revealing negative CD1a, CD3, CD20, CD23, and CD21 factors and positive S100 and LCA factors. After confirming the diagnosis,modified radical neck dissection was performed. In the next stage, the patient underwent chemotherapy with an R-CHOP regimen (Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Oncovin, Prednisone) and neck radiotherapy. 18 months after the formation of the tumor, no sign of recurrence or metastasis was observed in the patient.
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8. Pokuri VK, Merzianu M, Gandhi S, Baqai J, Loree TR, Bhat S. Interdigitating dendritic cell sarcoma. Journal of the National Comprehensive Cancer Network : JNCCN. 2015;13(2):128-32.
9. Steinman RM, Pack M, Inaba K. Dendritic cells in the T-cell areas of lymphoid organs. Immunological reviews. 1997;156:25-37.
10. Ninkovic S, Cole-Sinclair MF. Interdigitating dendritic cell sarcoma: diagnostic pitfalls, treatment challenges and role of transdifferentation in pathogenesis. Pathology. 2017;49(6):643-6.
11. De Pas T, Spitaleri G, Pruneri G, Curigliano G, Noberasco C, Luini A, et al. Dendritic cell sarcoma: an analytic overview of the literature and presentation of original five cases. Critical reviews in oncology/hematology. 2008;65(1):1-7.
12. Kairouz S, Hashash J, Kabbara W, McHayleh W, Tabbara IA. Dendritic cell neoplasms: an overview. American journal of hematology. 2007;82(10):924-8.
13. Helbig G, Wichary R, Pajak J, Budny M, Makowska M, Machura K, et al. Sustained remission after ABVD treatment for interdigitating dendritic cell sarcoma. Contemporary oncology (Poznan, Poland). 2015;19(1):83-5.
14. Madabhavi I, Patel A, Modi G, Anand A, Panchal H, Parikh S. Interdigitating dendritic cell tumor: A rare case report with review of literature. Journal of cancer research and therapeutics. 2018;14(3):690-3.
15. Zhou ZY, Sun RC, Yang SD, Liang JB, Rui J, Pan MH. Interdigitating dendritic cell tumor of the lymph node in the right submaxillary region: a case report and review of the literature. International journal of surgical pathology. 2011;19(1):88-92.
16. Jo S, Babb MJ, Hilsinger RL, Jr. Interdigitating dendritic cell sarcoma of cervical lymph nodes. Archives of otolaryngology--head & neck surgery. 2006;132(11):1257-9.
17. Sharma M, Ahsan F, Ah-See KW, McKean ME, Kain R, Chapman AD. Interdigitating dendritic cell sarcoma of the parotid gland. The Journal of laryngology and otology. 2006;120(3):244-6.
18. Ylagan LR, Bartlett NL, Kraus M. Interdigitating dendritic reticulum cell tumor of lymph nodes: case report with differential diagnostic considerations. Diagnostic cytopathology. 2003;28(5):278-81.
19. Nakamura S, Koshikawa T, Kitoh K, Nakayama A, Yamakawa M, Imai Y, et al. Interdigitating cell sarcoma: a morphologic and immunologic study of lymph node lesions in four cases. Pathology international. 1994;44(5):374-86.
20. Yamakawa M, Matsuda M, Imai Y, Arai S, Harada K, Sato T. Lymph node interdigitating cell sarcoma. A case report. American journal of clinical pathology. 1992;97(1):139-46.
2. Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. 2016;127(20):2375-90.
3. Feltkamp CA, van Heerde P, Feltkamp-Vroom TM, Koudstaal J. A malignant tumor arising from interdigitating cells; light microscopical, ultrastructural, immuno-and enzyme-histochemical characteristics. Virchows Archiv A, Pathological anatomy and histology. 1981;393(2):183-92.
4. Xue T, Jiang XN, Wang WG, Zhou XY, Li XQ. Interdigitating dendritic cell sarcoma: Clinicopathologic study of 8 cases with review of the literature. Annals of diagnostic pathology. 2018;34:155-60.
5. Saygin C, Uzunaslan D, Ozguroglu M, Senocak M, Tuzuner N. Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. Critical reviews in oncology/hematology. 2013;88(2):253-71.
6. Perkins SM, Shinohara ET. Interdigitating and follicular dendritic cell sarcomas: a SEER analysis. American journal of clinical oncology. 2013;36(4):395-8.
7. Pizzi M, Ludwig K, Palazzolo G, Busatto G, Rettore C, Altavilla G. Cervical follicular dendritic cell sarcoma: a case report and review of the literature. International journal of immunopathology and pharmacology. 2011;24(2):539-44.
8. Pokuri VK, Merzianu M, Gandhi S, Baqai J, Loree TR, Bhat S. Interdigitating dendritic cell sarcoma. Journal of the National Comprehensive Cancer Network : JNCCN. 2015;13(2):128-32.
9. Steinman RM, Pack M, Inaba K. Dendritic cells in the T-cell areas of lymphoid organs. Immunological reviews. 1997;156:25-37.
10. Ninkovic S, Cole-Sinclair MF. Interdigitating dendritic cell sarcoma: diagnostic pitfalls, treatment challenges and role of transdifferentation in pathogenesis. Pathology. 2017;49(6):643-6.
11. De Pas T, Spitaleri G, Pruneri G, Curigliano G, Noberasco C, Luini A, et al. Dendritic cell sarcoma: an analytic overview of the literature and presentation of original five cases. Critical reviews in oncology/hematology. 2008;65(1):1-7.
12. Kairouz S, Hashash J, Kabbara W, McHayleh W, Tabbara IA. Dendritic cell neoplasms: an overview. American journal of hematology. 2007;82(10):924-8.
13. Helbig G, Wichary R, Pajak J, Budny M, Makowska M, Machura K, et al. Sustained remission after ABVD treatment for interdigitating dendritic cell sarcoma. Contemporary oncology (Poznan, Poland). 2015;19(1):83-5.
14. Madabhavi I, Patel A, Modi G, Anand A, Panchal H, Parikh S. Interdigitating dendritic cell tumor: A rare case report with review of literature. Journal of cancer research and therapeutics. 2018;14(3):690-3.
15. Zhou ZY, Sun RC, Yang SD, Liang JB, Rui J, Pan MH. Interdigitating dendritic cell tumor of the lymph node in the right submaxillary region: a case report and review of the literature. International journal of surgical pathology. 2011;19(1):88-92.
16. Jo S, Babb MJ, Hilsinger RL, Jr. Interdigitating dendritic cell sarcoma of cervical lymph nodes. Archives of otolaryngology--head & neck surgery. 2006;132(11):1257-9.
17. Sharma M, Ahsan F, Ah-See KW, McKean ME, Kain R, Chapman AD. Interdigitating dendritic cell sarcoma of the parotid gland. The Journal of laryngology and otology. 2006;120(3):244-6.
18. Ylagan LR, Bartlett NL, Kraus M. Interdigitating dendritic reticulum cell tumor of lymph nodes: case report with differential diagnostic considerations. Diagnostic cytopathology. 2003;28(5):278-81.
19. Nakamura S, Koshikawa T, Kitoh K, Nakayama A, Yamakawa M, Imai Y, et al. Interdigitating cell sarcoma: a morphologic and immunologic study of lymph node lesions in four cases. Pathology international. 1994;44(5):374-86.
20. Yamakawa M, Matsuda M, Imai Y, Arai S, Harada K, Sato T. Lymph node interdigitating cell sarcoma. A case report. American journal of clinical pathology. 1992;97(1):139-46.
| Files | ||
| Issue | Vol 10 No 4 (2018) | |
| Section | Case Reports | |
| Keywords | ||
| Dendritic cells Interdigitating dendritic cell sarcoma Lymph node Neoplasm | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Salari A, Saffar H, Shirkhoda M. Head & Neck Interdigitating Dendritic Cell Sarcoma: A Case Report & Literature Review. Basic Clin Cancer Res. 2018;10(4):40-46.
