Changes Of CEA and CA15-3 Biomarkers in the Breast Cancer Patients following eight Weeks of Aerobic Exercise
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Abstract
Background: Exercise has positive effects on breast cancer evolution, including prevention, medical treatment, and aftercare clinical settings. Plus, elevated serum levels of CEA and CA15-3 as prognostic indicators were identified in patients with breast cancer. So, this study aimed to investigate the changes of CEA and CA15-3 biomarkers in the breast cancer patients following eight weeks of aerobic exercise.Methods: In this quasi-experimental study, 15 females with breast cancer with mean age (44.46±17.15 years), weight (70.53±5.18 kg) and body mass index (27.58±2.18 kg/m2) were randomly selected and performed aerobic training (for 8 weeks,3 sessions per week, with an intensity of 30%-60% heart rate reserve). Before and after the intervention, while all patients were fasting for 12 hours, the levels of CEA and CA15-3 were measured. The data obtained were analyzed, using paired sample t-test at a significance level of P<0.05.Results: Findings showed that the tumor marker (CA15-3) decreased following 8 weeks of aerobic exercise although it was not significant (P=0.091); CEA level did not change significantly after exercise, either (P=0.542), but a significant decrease was observed in body mass index, body fat percentage and weight values after exercise (p=0.001). Conclusion: Elevated CA15-3 and CEA which are considered as the diagnosis of metastatic breast cancer was not observed in the study. Exercise could reduce CA15- 3 insignificantly. Also, aerobic exercise for eight weeks improved body composition indices, without increasing the level of fatigue or stress values, which may contribute to the prevention of the cancer prevalence in middle-aged women.Guarneri V, Conte P. The curability of breast cancer and the treatment of advanced disease. Eur J Nucl Med Mol Imaging.2004; 31:149-56.
Taleghani F, Yekta ZP, Nasrabadi AN. Coping with breastcancer in newly diagnosed Iranian women. J Adv Nurs.2006; 54:265-72.
Lonning PE. Breast cancer prognostication and prediction:are we making progress? Ann Oncol. 2007; 18: 3–7.
Reis-Filho JS, Pusztai L. Gene expression profiling in breastcancer: classification, prognostication, and prediction. Lancet.2011; 37:1812–1823.
Valenzuela P. The contribution of CEA marker to CA15-3 inthe follow up of breast cancer. Eur J Gynaecol Oncol. 2003;24: 60-62.
Hashemi E, Montazeri A, Akbari ME, Njafi M, Haghighi SH, Kaviani A. Role of tumor markers in breast cancer recurrence.J Guilan University Med Sci. 2014; 14: 28-32.
Samy N, Ragab H.M, Maksoud E, Abd N, Shaalan M. Prognostic significance of serum Her2/neu, BCL2,CA15-3 and CEA in breast cancer patients: a shortfollow-up. Cancer Biomarkers. 2010; 6(2): 63-72.
Wang W, Xu X, Tian B, Wang Y, Du L,Sun T, Jing J. The diagnostic value of serum tumor markers CEA, CA19-9,CA125, CA15-3, and TPS in metastatic breast cancer. ClinicaChimica Acta. 2017; 470, 51-55.
Shao Y, Sun X, He Y, Liu C, Liu H. Elevated levels of serum tumor markers CEA and CA15-3 are prognostic parametersfor different molecular subtypes of breast cancer. PloS one.2015; 10(7): e0133830.
Adraskela K, Veisaki E, Koutsilieris M, Philippou A. Physical Exercise Positively Influences Breast Cancer Evolution.Clin Breast Cancer. 2017; 17(6):408-17.
Gordon LG, DiSipio T, Battistutta D, Yates P, Bashford J,Pyke C, Eakin E, Hayes SC. Cost-effectiveness of a pragmatic exercise intervention for women with breast cancer:results from a randomized controlled trial. Psycho-oncology.2017; 26(5):649-55.
Esfahbodi A, Fathie M, Moazami M, Mohammad Rahimi GH R. The Effect of Aerobic Training on the Level ofGrowth Hormone and 17-beta Estradiol Middle-aged Wom-en with Breast Cancer. Armaghane-danesh. 2016; 21: 563- 75.
Fathi M, Moazami M, Esfahbodi A, Mohammad Rahimi G. Effects of an Eight-Week Aerobic Training Program on Anthropometric Indices and Cardiorespiratory Fitness of Middle-Aged Women with Breast Cancer. Journal of Ergo¬nomics. 2016; 3:49-56.
Velez RR, Meneses-Echávez J, Jímenez EG, Río-Valle J, Correa-Bautista J. Influence of exercise training on markers of tumor microenvironment in breast cancer: a comprehen¬sive meta-analysis from 15 trials. The FASEB Journal. 2015; 29(1):916-1.
Kheyrdeh M, Daryanoosh F, Sadeghi Poor H.R, Khoshne¬shin Ghashghayi Z, Salesi M. Effects of an Eight-Week Aer¬obic Training on CA15-3 Marker,Growth Hormon and Insu¬lin of Middle-Aged Women with Breast Cancer. Journal of Research in Exercise Biologycal Sciences. 2014; 3: 88-96.
Il-Gyu Ko, Eung-Mi Park, Hye-Jung Choi, Jaehyun Yoo, Jong-Kyun Lee and Yong-Seok Jee. Proper Exercise De¬creases Plasma Carcinoembryonic Antigen Levels with the Improvement of Body Condition in Elderly Women. Tohoku J. Exp. Med.2014; 233: 17-23.
Segal R, Evans W, Johnson D, Smith J, Colletta S, Gayton J, et al. Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a rand¬omized controlled trial. J Clin Oncol. 2001; 19(3): 657-65.
Kurebayashi J, Nishimura R, Tanaka K, et al. Significance of serum tumor markers in monitoring advanced breast can¬cer patients treated with systemic therapy: a prospective study. Breast Cancer. 2004; 11: 389-95.
Cengiz B, Atabekoglu C, Cetinkaya E and Cengiz SD. Ef¬fect of hormone replacement therapy on serum levels of tu¬mor markers in healthy postmenopausal women. Maturitas. 2003; 46: 301-06.
Kolden GG, Strauman TJ, Ward A, Kuta J, Woods TE, Sch¬neider KL, et al. A pilot study of group exercise training (GET) for women with primary breast cancer: feasibility and health benefits. Psychooncology.2002; 11: 447-56.
Dethlefsen C, Lillelund C, Midtgaard J, Andersen C, Peder¬sen BK, Christensen JF, Hojman P. Exercise regulates breast cancer cell viability: systemic training adaptations versus acute exercise responses. Breast Cancer Res Treat. 2016; 159(3):469-79.
Conroy SM, Courneya KS, Brenner DR, Shaw E, O’Reil¬ly R, Yasui Y, Woolcott CG, Friedenreich CM. Impact of aerobic exercise on levels of IL-4 and IL-10: results from two randomized intervention trials. Cancer Med. 2016.5(9):2385-97.
del Carmen Sáez M, Barriga C, Jos J, Rodríguez AB, Or¬tega E. Exercise-induced stress enhances mammary tumor growth in rats: beneficial effect of the hormone melatonin. Mol and cell bioch. 2007; 294(1-2):19-24.
Lee, I.M., Paffenbarger, R.S. Jr. & Hsieh, C.C. Physical activity and risk of prostatic cancer among college alumni. Am. J. Epidemio, .1992;135: 169-79.
Lee, J.W., Park, K.D., Im, J.A., Hwang, H.J. & Kim, S.H. Serum carcinoembryonic antigen is associated with meta¬bolic syndrome in female Korean non-smokers. Clin. Chim. Acta .2011; 412: 527-30.
Kobayashi, L.C., Janssen, I., Richardson, H., Lai, A.S., Sp¬inelli, J.J. & Aronson, K.J. Moderate-to-vigorous intensity physical activity across the life course and risk of pre- and post-menopausal breast cancer. Breast Cancer Res. Treat. 2013; 139: 851-61.
Omidvari SH, Moslemi D, Larizadeh MH, Mosalaei A Mo¬hamadian Panah M, Ah,adloo N. Sesitivy and specificity of CA15-3 in detection of breast cancer recurrence. Journal of Kerman University of Medical Sciences.2005; 12: 181- 87.28.
Hammarstrom, S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin. Cancer Biol, 1999; 9: 67-81.
Fukuda, I., Yamakado, M. & Kiyose, H. Influence of smok¬ing on serum carcinoembryonic antigen levels in subjects who underwent multiphasic health testing and services. J. Med. Syst. 1998; 22: 89-93.
Ruibal Morell, A. CEA serum levels in non-neoplastic disease. Int. J. Biol. Markers. 1992;7: 160-66.
Carriquiry, L.A. & Pineyro, A. Should carcinoembryonic antigen be used in the management of patients with colorec¬tal cancer? Dis. Colon Rectum. 1999; 42: 921-29.
Bast R C, Bates S, Bredt A B. Clinical practice guidelines for the use of tumor markers in breast and colorectal cancer. J Clin Oncol. 1996;14:2843–77.
Shalamzari SA, Agha-Alinejad H, Alizadeh S, Shahbazi S, Khatib ZK, Kazemi A, Saei MA, Minayi N. The effect of exercise training on the level of tissue IL-6 and vascular en¬dothelial growth factor in breast cancer bearing mice. Iran J Basic Med Sci. 2014; 17(4):231.
Ganguly, A., Yeltsin, E. & Robbins, J. Identification of a carcinoembryonic antigen binding protein on monocytes. Biochem. Biophys. Res. Commun.2003; 311: 319-23.
de Boer MC, Wörner EA, Verlaan D, van Leeuwen PA. The mechanisms and effects of physical activity on breast can¬cer. Clin Breast Cancer. 2017; 17(4):272-8.
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| Issue | Vol 9 No 4 (2017) | |
| Section | Original Articles | |
| Keywords | ||
| Exercise Carcinoembryonic Antigen Cancer Antigen 15-3 Women Breast Cancer | ||
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