Epidemiologic Study of Patients with Cancer Admitted to Intensive Care

  • Roghoyeh Honargoo Graduate Student of Intensive Care Nursing, Nasibe Sari School of Nursing and Midwifery, Student Research Committee of Mazandaran University of Medical Sciences, Sari, Iran
  • Vida Shafipour Nasibeh Nursing and Midwifery Faculty, Mazandaran University of Medical Sciences, Sari, Iran.
  • Mahmood Moosazadeh Health Sciences Research center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran,
  • Ravanbakhsh Esmaeili Assistant Professor, Faculty Member, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Keywords: Cancer, Neoplasms, Hospital, Epidemiology


Background: Cancer is the second leading cause of death in the world and the third cause of death in Iran. Evidence suggests that some of the cancer patients are admitted to intensive care units according to their demand. The need for hospitalization in this ward can vary according to different factors such as gender, age, type of disease, etc. Therefore, this study has been designed in order to investigate the epidemiology of cancer patients admitted to intensive care units.Methods: This is a descriptive cross-sectional study. The study population includes all cancer patients admitted to the intensive care units of Mazandaran University of Medical Sciences in the years 2013-2016. The records of all patients were included in the study through census and the necessary information was extracted. Data were analyzed using SPSS software version 24 in terms of percentage, mean, standard deviation through Chi-square test.Results: 12273 patients were admitted to intensive care units during the study period, among whom 380 (3.9%) were cancer patients. The age range of patients with cancer was between 16 and 96 years old with the mean value of 60.11 years and the standard deviation of 17.49 and the majority of patients (52.4%) were males. The frequency of patients in terms of the type of cancer includes 40% of gastrointestinal cancer, 20% of brain cancer, 9.2% of lung cancer, 6.6% of kidney cancer, 6.6% of breast cancer, 5.5% of blood cancer, and 11.8% of other cancers. The mortality rate of cancer patients admitted to ICUs was 36.1%. The frequency of patients with gastrointestinal, lung, blood, kidney and brain cancers admitted in the intensive care units in males was significantly higher than females (p <0.001).Conclusion: The results of this study indicate that, despite the need to receive intensive care in cancer patients due to the lack of beds in these wards, unfortunately, cancer patients are less admitted in these wards, therefore, practical measures should be considered in this regard, such as the establishment of intensive care units for cancer patients.


Aminzadeh A, Motaghi A, Mohammadi E. Epidemiologic study of oral and paraoral malignancies in one cancer referral center in Isfahan during a 5-year period. Journal of Isfahan Dental School. 2013;8(6):560-566.[in persian] 2. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral oncology. 2009;45(4-5):309-16. 3. Torre LA, Siegel RL, Ward EM, Jemal A. Global cancer incidence and mortality rates and trends—an update. Cancer Epidemiology and Prevention Biomarkers. 2016;25(1):16-27. 4. van Leeuwen RW, Jansman FG, van den Bemt PM, de Man F, Piran F, Vincenten I, et al. Drug–drug interactions in patients treated for cancer: a prospective study on clinical interventions. Annals of Oncology. 2015;26(5):992-7.

Jafari A, Najafi SH, Moradi F, Kharazifard MJ, Khami MR. Delay in the diagnosis and treatment of oral cancer. Journal of Dentistry. 2013;14(3):146-150.[in persian]

Jemal A, Center MM, DeSantis C, Ward EM. Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiology and Prevention Biomarkers. 2010;19(8):1893907.

Yavari M, Ardhali H, Moinim M. Investigating the compliance rate of standards in the intensive care unit of selected hospitals in Tehran. Scientific Journal of the Medical Council of the Islamic Republic of Iran.2015;33(2):131-4.[ in persian]

Fernandez-Ortega J, Herrero Meseguer J, Martinez Garcia P. Guidelines for specialized nutritional and metabolic support in the critically-ill patient. Update. Consensus semicyuc-senpe: Indications, timing and routes of nutrient delivery. Nutricion hospitalaria.2011;26(2):7-11.

Gunther A. Skin conductance variability and stressful exposures in critical care: Inst for fysiologi och farmakologi/Dept of Physiology and Pharmacology. 2016;40:190-215.

Jarahzadeh MH, Emamimeybodi AH, Halvani A, Mirjalili MR, Farnia F. The Prognosis of Patients with Admission Hypomagnesemia in Intensive Care Unit Related to APACHE II, III and SOFA Scores. journal of Ilam university of medical sciences. 2017;25(1):45-53.[in persian]

Van Sambeek J, Cornelissen F, Bakker P, Krabbendam JJ. Models as instruments for optimizing hospital processes: a systematic review. International journal of health care quality assurance. 2010;23(4):356-77.

Kwizera A, Dunser M, Nakibuuka J. National intensive care unit bed capacity and ICU patient characteristics in a low income country. BMC research notes. 2012;5(1):475-481.

Halpern NA, Pastores SM, Oropello JM, Kvetan V. Critical care medicine in the United States: addressing the intensivist shortage and image of the specialty. Critical care medicine 2013;41(12):2754-16.

Aksoy Y, Kaydu A, Sahin OF, Kacar CK. Analysis of cancer patients admitted to intensive care unit. Northern clinics of Istanbul. 2016;3(3):217-21.

Monique M,Bos M, Keizer N, Meynaar I, Bakhshi-Raiez F, Jonge E. Outcomes of cancer patients after unplanned admission to general intensive care units. Acta oncologica. 2012;51(7):897-905.

Jonge E, Bos M. Patients with cancer on the ICU: the times they are changing. Critical Care. 2009;13(2):122-123.

Xia R, Wang D. Intensive care unit prognostic factors in critically ill patients with advanced solid tumors: a 3-year retrospective study. BMC cancer. 2016;16(1):188-295.

Hawari FI, Nazer LH, Addassi A, Rimawi D, Jamal K. Predictors of ICU admission in patients with cancer and the related characteristics and outcomes: a 5-year registry-based study. Critical care medicine. 2016;44(3):548-53.

Shokrzadeh M, Mohammadpour A, Tabari YS, Parvizi Almani S. Investigating the Distribution of ERCC2 (rs13181) Gene Polymorphism in Gastric Cancer Patients in Mazandaran: A Case-control Study. Journal of Genetic Resources. 2017;3(1):54-60.

Farvid MS, Malekshah AF, Pourshams A, Poustchi H, Sepanlou SG, Sharafkhah M, et al. Dairy food intake and all-cause, cardiovascular disease, and cancer mortality: The Golestan Cohort Study. American journal of epidemiology. 2017;185(8):697-711.

Bird G, Farquhar-Smith P, Wigmore T, Potter M, Gruber P. Outcomes and prognostic factors in patients with haematological malignancy admitted to a specialist cancer intensive care unit: a 5 yr study. British journal of anaesthesia. 2012;108(3):452-9.

Zafra M, Carrillo A, Vicente MA, Sánchez Canovas M, Ivars Rubio A, Ballester Navarro I, et al. Long-term survival and performance status of cancer patients after discharge from ICU (intensive care unit). American Society of Clinical Oncology; 2018;36(15):18744. 23. Soares M, Caruso P, Silva E, Teles JM, Lobo SM, Friedman G, et al. Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study. Crit Care Med. 2010;38(1):9-15.

Schiavone MB, Moukarzel L, Leong K, Zhou QC, Afonso AM, Iasonos A, et al. Surgical site infection reduction bundle in patients with gynecologic cancer undergoing colon surgery. Gynecologic oncology. 2017;147(1):115-9.

Girard TD, Alhazzani W, Kress JP, Ouellette DR, Schmidt GA, Truwit JD, et al. An official American Thoracic Society/American College of Chest Physicians clinical practice guideline: liberation from mechanical ventilation in critically ill adults. Rehabilitation protocols, ventilator liberation protocols, and cuff leak tests. American journal of respiratory and critical care medicine. 2017;195(1):120-33.

Saillard C, Mokart D, Lemiale V, Azoulay E. Mechanical ventilation in cancer patients. Minerva Anestesiol. 2014;80(6):712-25.

How to Cite
Honargoo R, Shafipour V, Moosazadeh M, Esmaeili R. Epidemiologic Study of Patients with Cancer Admitted to Intensive Care. Basic Clin Cancer Res. 10(4):9-15.