Changes Of CEA and CA15-3 Biomarkers in the Breast Cancer Patients following eight Weeks of Aerobic Exercise

  • Azar Esfahbodi M.Sc graduated in SportsPhysiology, Faculty of physicaleducation and sport sciences, Islamic Azad University, Bojnord, Iran.
  • Mehrdad Fathi Associate Professor ofDepartment of Sports Physiology,Faculty of physical education and sport sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
  • Gholam Rasul Mohammad Rahimi Ph.D. Student in SportsPhysiology, Faculty of physical education and sport sciencesFerdowsi university of Mashhad, Mashhad, Iran.
Keywords: Exercise, Carcinoembryonic Antigen, Cancer Antigen 15-3, Women, Breast Cancer


Background:Physical activity has beneficial effects on the elderly susceptible to the development of cancers, through maintaining a healthy body condition and improving the state of disease. In the present study, we investigated the variation of cancer-related biomarkers, such as Carcinoembryonic Antigen (CEA) and Cancer Antigen 15-3 (CA 15-3) following eight weeks of aerobic exercise in middle-aged women with breast cancer.Methods: In this quasi-experimental study, 15 females with breast cancer with mean age (44.46±17.15 years of age), weight (70.53±5.18 kg) and body mass index (27.58±2.18 kg/m2) were selected and considered as the experimental group. The exercise program consisted of 8 weeks of aerobic exercise; three sessions per week for 40-60 minutes and with an intensity of 30%-60% heart rate reserve (HRR). Before and after the experiment, while all patients were fasting for 12 hours and did not have any vigorous physical activity for 24 hours, the level of CEA and CA15-3 was measured. Data were analyzed by paired sample t-test at a significance level of P<0.05.Results:Findings showed that the tumor markers (CEA and CA15-3) levels did not change significantly after 8 weeks of aerobic exercise (P=0.542 and P=0.091); while there was a significant decrease (p=0/001) in body mass index, body fat percentage and weight in middle-aged women with breast cancer‎.Conclusion: We suggest that exercise for 3 days per week improves body composition indices, without increasing the level of fatigue or stress values, which may contribute to prevent cancer prevalence in elderly women.


Guarneri V, Conte P. The curability of breast cancer and the treatment of advanced disease. Eur J Nucl Med Mol Imaging.2004; 31:149-56.

Taleghani F, Yekta ZP, Nasrabadi AN. Coping with breastcancer in newly diagnosed Iranian women. J Adv Nurs.2006; 54:265-72.

Lonning PE. Breast cancer prognostication and prediction:are we making progress? Ann Oncol. 2007; 18: 3–7.

Reis-Filho JS, Pusztai L. Gene expression profiling in breastcancer: classification, prognostication, and prediction. Lancet.2011; 37:1812–1823.

Valenzuela P. The contribution of CEA marker to CA15-3 inthe follow up of breast cancer. Eur J Gynaecol Oncol. 2003;24: 60-62.

Hashemi E, Montazeri A, Akbari ME, Njafi M, Haghighi SH, Kaviani A. Role of tumor markers in breast cancer recurrence.J Guilan University Med Sci. 2014; 14: 28-32.

Samy N, Ragab H.M, Maksoud E, Abd N, Shaalan M. Prognostic significance of serum Her2/neu, BCL2,CA15-3 and CEA in breast cancer patients: a shortfollow-up. Cancer Biomarkers. 2010; 6(2): 63-72.

Wang W, Xu X, Tian B, Wang Y, Du L,Sun T, Jing J. The diagnostic value of serum tumor markers CEA, CA19-9,CA125, CA15-3, and TPS in metastatic breast cancer. ClinicaChimica Acta. 2017; 470, 51-55.

Shao Y, Sun X, He Y, Liu C, Liu H. Elevated levels of serum tumor markers CEA and CA15-3 are prognostic parametersfor different molecular subtypes of breast cancer. PloS one.2015; 10(7): e0133830.

Adraskela K, Veisaki E, Koutsilieris M, Philippou A. Physical Exercise Positively Influences Breast Cancer Evolution.Clin Breast Cancer. 2017; 17(6):408-17.

Gordon LG, DiSipio T, Battistutta D, Yates P, Bashford J,Pyke C, Eakin E, Hayes SC. Cost-effectiveness of a pragmatic exercise intervention for women with breast cancer:results from a randomized controlled trial. Psycho-oncology.2017; 26(5):649-55.

Esfahbodi A, Fathie M, Moazami M, Mohammad Rahimi GH R. The Effect of Aerobic Training on the Level ofGrowth Hormone and 17-beta Estradiol Middle-aged Wom-en with Breast Cancer. Armaghane-danesh. 2016; 21: 563- 75.

Fathi M, Moazami M, Esfahbodi A, Mohammad Rahimi G. Effects of an Eight-Week Aerobic Training Program on Anthropometric Indices and Cardiorespiratory Fitness of Middle-Aged Women with Breast Cancer. Journal of Ergo¬nomics. 2016; 3:49-56.

Velez RR, Meneses-Echávez J, Jímenez EG, Río-Valle J, Correa-Bautista J. Influence of exercise training on markers of tumor microenvironment in breast cancer: a comprehen¬sive meta-analysis from 15 trials. The FASEB Journal. 2015; 29(1):916-1.

Kheyrdeh M, Daryanoosh F, Sadeghi Poor H.R, Khoshne¬shin Ghashghayi Z, Salesi M. Effects of an Eight-Week Aer¬obic Training on CA15-3 Marker,Growth Hormon and Insu¬lin of Middle-Aged Women with Breast Cancer. Journal of Research in Exercise Biologycal Sciences. 2014; 3: 88-96.

Il-Gyu Ko, Eung-Mi Park, Hye-Jung Choi, Jaehyun Yoo, Jong-Kyun Lee and Yong-Seok Jee. Proper Exercise De¬creases Plasma Carcinoembryonic Antigen Levels with the Improvement of Body Condition in Elderly Women. Tohoku J. Exp. Med.2014; 233: 17-23.

Segal R, Evans W, Johnson D, Smith J, Colletta S, Gayton J, et al. Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a rand¬omized controlled trial. J Clin Oncol. 2001; 19(3): 657-65.

Kurebayashi J, Nishimura R, Tanaka K, et al. Significance of serum tumor markers in monitoring advanced breast can¬cer patients treated with systemic therapy: a prospective study. Breast Cancer. 2004; 11: 389-95.

Cengiz B, Atabekoglu C, Cetinkaya E and Cengiz SD. Ef¬fect of hormone replacement therapy on serum levels of tu¬mor markers in healthy postmenopausal women. Maturitas. 2003; 46: 301-06.

Kolden GG, Strauman TJ, Ward A, Kuta J, Woods TE, Sch¬neider KL, et al. A pilot study of group exercise training (GET) for women with primary breast cancer: feasibility and health benefits. Psychooncology.2002; 11: 447-56.

Dethlefsen C, Lillelund C, Midtgaard J, Andersen C, Peder¬sen BK, Christensen JF, Hojman P. Exercise regulates breast cancer cell viability: systemic training adaptations versus acute exercise responses. Breast Cancer Res Treat. 2016; 159(3):469-79.

Conroy SM, Courneya KS, Brenner DR, Shaw E, O’Reil¬ly R, Yasui Y, Woolcott CG, Friedenreich CM. Impact of aerobic exercise on levels of IL-4 and IL-10: results from two randomized intervention trials. Cancer Med. 2016.5(9):2385-97.

del Carmen Sáez M, Barriga C, Jos J, Rodríguez AB, Or¬tega E. Exercise-induced stress enhances mammary tumor growth in rats: beneficial effect of the hormone melatonin. Mol and cell bioch. 2007; 294(1-2):19-24.

Lee, I.M., Paffenbarger, R.S. Jr. & Hsieh, C.C. Physical activity and risk of prostatic cancer among college alumni. Am. J. Epidemio, .1992;135: 169-79.

Lee, J.W., Park, K.D., Im, J.A., Hwang, H.J. & Kim, S.H. Serum carcinoembryonic antigen is associated with meta¬bolic syndrome in female Korean non-smokers. Clin. Chim. Acta .2011; 412: 527-30.

Kobayashi, L.C., Janssen, I., Richardson, H., Lai, A.S., Sp¬inelli, J.J. & Aronson, K.J. Moderate-to-vigorous intensity physical activity across the life course and risk of pre- and post-menopausal breast cancer. Breast Cancer Res. Treat. 2013; 139: 851-61.

Omidvari SH, Moslemi D, Larizadeh MH, Mosalaei A Mo¬hamadian Panah M, Ah,adloo N. Sesitivy and specificity of CA15-3 in detection of breast cancer recurrence. Journal of Kerman University of Medical Sciences.2005; 12: 181- 87.28.

Hammarstrom, S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin. Cancer Biol, 1999; 9: 67-81.

Fukuda, I., Yamakado, M. & Kiyose, H. Influence of smok¬ing on serum carcinoembryonic antigen levels in subjects who underwent multiphasic health testing and services. J. Med. Syst. 1998; 22: 89-93.

Ruibal Morell, A. CEA serum levels in non-neoplastic disease. Int. J. Biol. Markers. 1992;7: 160-66.

Carriquiry, L.A. & Pineyro, A. Should carcinoembryonic antigen be used in the management of patients with colorec¬tal cancer? Dis. Colon Rectum. 1999; 42: 921-29.

Bast R C, Bates S, Bredt A B. Clinical practice guidelines for the use of tumor markers in breast and colorectal cancer. J Clin Oncol. 1996;14:2843–77.

Shalamzari SA, Agha-Alinejad H, Alizadeh S, Shahbazi S, Khatib ZK, Kazemi A, Saei MA, Minayi N. The effect of exercise training on the level of tissue IL-6 and vascular en¬dothelial growth factor in breast cancer bearing mice. Iran J Basic Med Sci. 2014; 17(4):231.

Ganguly, A., Yeltsin, E. & Robbins, J. Identification of a carcinoembryonic antigen binding protein on monocytes. Biochem. Biophys. Res. Commun.2003; 311: 319-23.

de Boer MC, Wörner EA, Verlaan D, van Leeuwen PA. The mechanisms and effects of physical activity on breast can¬cer. Clin Breast Cancer. 2017; 17(4):272-8.

How to Cite
Esfahbodi A, Fathi M, Mohammad Rahimi GR. Changes Of CEA and CA15-3 Biomarkers in the Breast Cancer Patients following eight Weeks of Aerobic Exercise. BCCR. 9(4):4-2.
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