Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 6 1 2014 01 01 2 10 EN Elham Kalantari Oncopathology Research Center, Iran University of Medical Sciences, Tehran Zahra Madjd Oncopathology Research Center, Iran University of Medical Sciences, Tehran AND Department of Pathology, Iran University of Medical Sciences, Tehran AND Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran 2013 12 16 2014 04 01 A long-lasting problem in the analysis of tissue samples is the time-consuming and repetitive process of histologic preparation and pathologic review of tissue sections. These two critical factors, innate nonuniformity in preparation and subjectivity of analysis, therefore limit the scientific and statistical thoroughness of tissue based studies. Employing tissue microarray (TMA) technique provides a potential solution to each of these problems. This review discusses the methods of creating tissue microarrays, the advantages and disadvantages of the technology, analysis methods, and recent TMA applications. https://bccr.tums.ac.ir/index.php/bccrj/article/view/64 https://bccr.tums.ac.ir/index.php/bccrj/article/download/64/pdf