Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 17 1 2026 04 27 241 251 Azin Nahvijou Cancer Research Center of Cancer Institute Taha Jariri 0009-0006-3020-5746 2025 07 26 2025 12 29 Background: The increasing complexity of cancer care and rapid advancements in digital technologies have led to the emergence of smart cancer hospitals as innovative solutions to contemporary healthcare challenges. Objective: This review aims to provide a comprehensive overview of the essential architectural, technological, and operational requirements for designing and operating smart cancer hospitals. Methods: A synthesis of recent literature and global case studies was conducted to identify core elements defining smart cancer hospitals, focusing on technology integration, adaptable architectural design, environmental considerations, IT infrastructure, and multidisciplinary care. Results: Smart cancer hospitals incorporate advanced technologies such as artificial intelligence, the Internet of Things (IoT), big data analytics, and telemedicine to enhance diagnostic accuracy, treatment efficiency, and patient experience. Modular and adaptable designs enable rapid technological updates and spatial flexibility. Sustainable architectural elements contribute to improved patient outcomes and staff well-being. Robust IT infrastructure ensures secure, interoperable clinical data exchange. Integration of multidisciplinary collaboration areas, palliative care, and psychosocial support fosters holistic, patient-centered care. Conclusion: This review outlines critical components necessary for creating future- ready smart cancer hospitals that combine technological advancement with human-centered care. These insights aim to assist architects, healthcare providers, and policymakers in developing oncology facilities responsive to evolving cancer care needs. https://bccr.tums.ac.ir/index.php/bccrj/article/view/579