Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 15 2 2024 02 28 94 102 Bita Eslami Breast Diseases Research Center (BDRC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Sadaf Alipour Breast Diseases Research Center (BDRC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Shiller Hessamiazar Breast Diseases Research Center (BDRC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran 2023 12 09 2024 01 20 Chemotherapy-induced alopecia (CIA) is one of the side effects of chemotherapy that is the most traumatic aspect of treatment for more than half of the patients. CIA is associated with increased psychosocial stress regarding body image, self-esteem, and sexuality. It is estimated that 60-85% of individuals who received chemotherapy treatment for cancer experienced some degree of CIA. Various techniques have been used to prevent CIA, including scalp compression, scalp cooling, and medical treatments. Herein, we provide a review of scalp cooling methods, advantages and disadvantages, requirements, and related papers. https://bccr.tums.ac.ir/index.php/bccrj/article/view/508