Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 16 3 2025 09 14 171 179 Dr. Anant Pore Consultant at Sarvoday Hospital, Paratwada Dr. Ravi Bang Consultant at Care Diagnostic Centre, Nagpur Dr. Sushantkumar Ikhar Assistant Professor (Medical Oncologist) at DMIMS, Sawangi, Wardha Dr. Sayali Pore Junior resident at Panjabrao Deshmukh Meemorial Medical Institute, Amravati Dr. Chetan Ronghe Consultant at Sarvoday Hospital, Paratwada 2023 05 05 2025 07 09 A 28-year-old patient reported having a lump in the right lower abdominal and pelvic area for the last 21 days along with pain, anorexia, fever, and nausea. After a thorough investigation, an AP scanogram of the patient showed a clearly defined lump in this area. Histopathological examination showed mesenteric fibromatosis. Resection and anastomosis were done. Our case is one of the few known cases of the extremely rare condition fibromatosis of the mesentery. These tumours present a diagnostic and therapeutic difficulty due to their rarity. These tumours are still asymptomatic, however they frequently appear as an asymptomatic mass. There aren't any obvious therapy options. The preferred method of treatment is surgical excision with a wide margin; we underwent the same technique and the prognosis was good. Numerous single case reports with various and peculiar appearances and their difficulties exist. This case report aims to offer current understanding of mesenteric fibromatosis as well as our clinical experience with the presented patient. Following surgery, the patient did well, and a three-month follow-up revealed a typical recovery. https://bccr.tums.ac.ir/index.php/bccrj/article/view/479