Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 13 3 2022 08 31 235 238 EN Azin Alizadehasl Shaheed Rajaie Cardiovascular Medical & Research Center, Cardio-Oncology Research Center, Iran University of Medical Science, Tehran, Iran Niloufar Akbari Parsa Dr. Heshmat Hospital, Guilan University of Medical Sciences, Rasht, Iran Feridoun Noohi Shaheed Rajaie Cardiovascular Medical & Research Center, Iran University of Medical Science, Tehran, Iran Reza Golpira Shaheed Rajaie Cardiovascular Medical & Research Center, Iran University of Medical Science, Tehran, Iran Amir Abdi Islamic Asad Univeristy, Tehran Medical Branch, Tehran, Iran Amir Hossein Emami Emam Khomeni Hispital, Tehran University of Medical Sciences, Tehran, Iran Asadollah Moosavi Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran Ghasem Janbabaei Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran 2022 04 29 2022 07 24 Advances in cancer treatment have resulted in a growing number of cancer survivors.However, powerful treatments such as chemotherapy, radiation treatments, and some cancer drugs are not without risks, including the potential for serious, long-term damage to the heart. Cardiology and oncology specialists often collaborate to mitigate these risks when treating cancer patients. This joining is known as cardio-oncology. The main goals of cardio-oncology are to screen for and actively manage modifiable cardiovascular risk factors and diseases in cancer patients. Cardio-oncology plays an increasingly active role at every stage of cancer therapy, including baseline risk assessment pretreatment, surveillance and prevention during treatment, response to acute complications, and assessment of survivors’ post-cardiotoxic treatments. Cancer treatment has been optimized through new treatment strategies. The first cardio-oncology clinic in Iran was instituted about 4 years ago (2017) at Shaheed Rajaei Cardiovascular Medical and Research Center in Tehran, which is the first cardio-oncology clinic in the Middle East. It provides care for cancer patients with a history of cardiovascular disease or risk for cardiotoxicity during cancer therapy. Also, all patients are enrolled in the multicenter cardio-oncology Toxicity Registry research database, and 13 other hospitals from different centers in the whole country are involved in the registry. The establishment of the cardio-oncology clinic with a focus on the patient registry is discussed in this article. https://bccr.tums.ac.ir/index.php/bccrj/article/view/428