Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 13 4 2022 11 12 258 271 EN Mehdi Karimi Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Kamran Roudini Department of Internal Medicine, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Iran Abolfazl Zendehdel Geriatric Department, Associate Professor of Internal Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran AND Family Medicine Department, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran Fatemeh Toorang Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran AND Cancer Research Center of Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran Soraiya Ebrahimpour-Koujan Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran AND Cancer Research Center of Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran AND Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2022 05 11 2022 07 31  Background:DNA oxidation is one of the essential destructive effects of reactive oxygen species (ROS) on the cell membrane macromolecules leading to the deformation of cellular DNA. The most abundant oxidative DNA product on which most studies have focused is re-oxidized DNA, 8 oxo-deoxyguanosine (8-oxodG). This deformation of cellular DNA is associated with various cancer initiation and progression. DNA damage can be a cancer marker including 8-oxodG, thymidine glycol, 8-oxoadenine, etc. DNA oxidation is affected by environmental and non-environmental factors. Age, diet, and metabolism are at the heart of this process. This review study summarizes the types of cancer-related DNA oxidation that serve as a cancer biomarker. Also we will look at the factors influencing their formation. https://bccr.tums.ac.ir/index.php/bccrj/article/view/427