Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 13 4 2022 10 22 239 244 Sheeba Bhardwaj Pandit B D Sharma Post Graduate Institution of Medical Sciences, Rohtak, Haryana, India Vivek Kaushal Pandit B D Sharma Post Graduate Institution of Medical Sciences, Rohtak, Haryana, India Diptajit Paul Pandit B D Sharma Post Graduate Institution of Medical Sciences, Rohtak, Haryana, India 2022 04 12 2022 09 07 Background: The incidence of malignant esophageal-respiratory fistulas in esophageal cancer patients is not so frequent. The fistula development in esophageal cancer may be due to advanced disease or a radiotherapy-related complication. Rarely, a pulmonary abscess may develop, which is the most dreadful complication resulting in dismal outcomes. Here, we reported 2-cases of esophageal-respiratory fistula; one with esophageal bronchial fistula and the other with esophageal pleural fistula.  Case reports: A 46-year-aged man presented with complaints of difficulty in swallowing for 4 months. CECT chest showed an esophageal growth of 8.5 cm in the lower esophagus. The patient received palliative radiotherapy followed by palliative chemotherapy and showed some improvement in dysphagia. Nine months after the start of treatment, the patient’s dysphagia began to worsen, and he was put on oral metronomic chemotherapy. After 1-year of metronomic chemotherapy, the patient developed cough and chest pain and was diagnosed with an esophageal-pleural fistula with chest wall collection and pleural effusion. The patient was managed conservatively and later lost to follow-up. Another 65-year-old patient presented with dysphagia for 3-months. CECT chest showed an esophageal growth of 5.5 cm in the middle esophagus. The patient received palliative radiotherapy, after which the dysphagia improved. In 3rd month of follow up patient’s dysphagia worsened; barium swallow showed esophageal- bronchial fistula. The patient was managed symptomatically and later lost to follow-up. Conclusions: Fistula formation and subsequent abscess results in a poor prognosis.With advancing disease and compromised general condition of the patient, palliation of symptoms is a significant challenge. Treatment becomes difficult due to the rare occurrence of fistulas and the non-standardization of the treatment protocol. Invasive treatment includes esophageal-pulmonary resection, endoscopic placement of self-expandable covered stents, drainage of empyema and obliteration of empyema cavity, esophageal diversion, and non-invasive treatment includes best supportive care. However, even with appropriate treatment, the outcome is dismal. https://bccr.tums.ac.ir/index.php/bccrj/article/view/426