Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 13 2 2022 02 12 92 104 EN Arash Abdolmaleki Department of Bioinformatics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran Aida Karimian Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran. Asadollah Asadi Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran. Hussein A. Ghanimi College of Nursing, University of Al-Ameed, Karbala, PO Box 198, Iraq. Muhammad Akram Department of Eastern Medicine, Government College University Faisalabad-Pakistan. 2021 09 15 2021 11 16 Cancer is a genetic illness that develops for a variety of reasons, including the activation of onco-genes, the failure of tumor suppressor genes, or mutagenesis induced by environmental stimuli. This article was produced using data from the journals PubMed, Nature, Science Direct, Springer, and Elsevier. Oncogenes are altered forms of normal proto-oncogenic genes that are important for cell proliferation, development, and regulation. The transformation of a gene to an oncogene is caused by translocation, chromosomal translocation, or gene mutation due to addition, deletion, duplication, or viral infection. To limit malignant cell development, these oncogens are targeted by medications or the RNAi system. Various molecular biology methods for cancer detection and treatment have been developed, including retroviral therapy, oncogene silencing, and alterations in tumor suppressor genes. Among all the techniques used, RNAi, zinc finger nucleases, and CRISPR have a greater chance of reaching a cancer-free planet. https://bccr.tums.ac.ir/index.php/bccrj/article/view/401 https://bccr.tums.ac.ir/index.php/bccrj/article/download/401/485