Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 9 4 2018 04 07 32 39 EN Reza Ghalehtaki Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Maisa Yamrali Radiation Oncology Department, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Borna Farazmand Radiation Oncology Department, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Armaghan Fard-Esfahani Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran Kamran Alimoghaddam The Hematology-Oncology Research Center and Stem Cell Transplantation, Tehran University of Medical Sciences, Tehran, Iran Peiman Haddad Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. 2017 10 15 2018 02 17 Soft tissue metastases are extremely rare in differentiated thyroid cancers. We hereby present a man with a history of papillary thyroid cancer (PTC) at the age of 46, who was referred to cancer Institute due to raised serum thyroglobulin (Tg) and a new mass in the thigh. Imaging studies were suggestive of recurrence of the disease in the tumor bed, neck nodes and lungs, and also a mass in his left thigh, based on positron emission tomography (PET) scan, without radioactive iodine uptake. The excision of the mass revealed metastatic PTC. After management of symptomatic local recurrence with external beam radiotherapy (EBRT), he received sorafenib. After three years he is doing well and serum Tg is stable.  https://bccr.tums.ac.ir/index.php/bccrj/article/view/260 https://bccr.tums.ac.ir/index.php/bccrj/article/download/260/04