Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 4 1&2 2012 02 01 7 10 EN Farnaz Amoozgar Hashemi Radiation Oncology Department, Cancer Institute,Tehran University of Medical Sciences, Tehran, Iran Masoud Jamali Radiation Oncology Department, Cancer institute,Tehran University of Medical Science(TUMS), Iran Mahsa Mohsenolhosseini Radiation Oncology Department, Cancer institute,Tehran University of Medical Science(TUMS), Iran Mehran Jamali Radiation Oncology Department, Cancer institute,Tehran University of Medical Science(TUMS), Iran 2012 05 13 2012 10 30 Introcduction: Pigmented villonodular synovitis (PVS) is rare, benign and proliferative disorder of synovium which consists of villous and/ or nodular formations in joints.Diagnosis is determined by clinical features, aspiration of the joint, radiographic features and magnetic resonance imaging (MRI).The definitive treatment is the complete resection of affected tissue by open or arthroscopic synovectomy. Radiotherapy is recommended as an additive treatment in the control of recurrent or refractory disease. Case Presentation: we report a case of young woman with biopsy proven of PVS who after total synvectomy was referred for adjuvant radiotherapy.she received 36 Gy in 18 fractions and 12 month after treatment she has no sign of recurrence. Discussion: PVS is a rare benign disorder of synovium which is managed with surgical resection.Radiotherapy can be used as an additional treatment to increase local control.   https://bccr.tums.ac.ir/index.php/bccrj/article/view/24 https://bccr.tums.ac.ir/index.php/bccrj/article/download/24/pdf