Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 9 2 2017 11 20 13 19 EN Sanambar Sadighi Hematology and Medical Oncology Department,Cancer Research Center of Iran Cancer Institute,Tehran University of Medical Sciences,Tehran, Iran Simin Dashti-Khavidaki Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Foroud Shahbazi Department of Pharmacology, Toxicology and Pharmaceutical Care, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran. Mehrzad Mirzania Hematology and Medical Oncology Department, Cancer Research Center of Iran Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. Farhad Shahi Hematology and Medical Oncology Department, Cancer Research Center of Iran Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. Alireza Abdollahi Department of Pathology, Valie-Asr Hospital,Tehran University of Medical Sciences, Tehran, Iran. Mohammad Ghahremani Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences 2017 05 29 2017 11 15 Anti-cancer potential of silymarin have been shown in cell culture. However, regarding this matter no prospective clinical study has been done. In a randomized double blind pilot study, we compared effects of addition of standard chemotherapy along with silymarin (420mg/day) versus placebo on clinical response of advanced tumors after three cycles of cisplatin-based chemotherapy. There was no significant difference in tumor size after three consecutive chemotherapy courses but a trend toward lower metastasis rate in chemotherapy + silymarin group. Concomitant use of silymarin along with chemotherapy was very well tolerated but didn’t significantly increase clinical response. Due to trend toward significant lower metastasis in silymarin group, further study with larger sample size is needed to better clarify probable role of adjunctive therapy with silymarin in patients with solid tumors.     https://bccr.tums.ac.ir/index.php/bccrj/article/view/238 https://bccr.tums.ac.ir/index.php/bccrj/article/download/238/02