Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 3 2 2016 10 09 42 45 EN Samad Muhammadnejad Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Ahad Muhammadnejad Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Zohreh Mazaheri Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran Farrokh Tirgari Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Mohammad-Ali Oghabian Research Center for Sciences and Technology in Medicine, Tehran University of Medical Sciences Tehran, Iran Maryam Kazem haghighi Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Saeid Amanpour Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran, AND Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran 2011 10 30 2011 10 30 Background: Androgen receptors (AR) play an important role in proliferation of cancerous prostatic cells and prevention of apoptotic signaling. Current drugs cannot inhibit the activity of these receptors very well. Establishment of appropriate animal models is essential for discovery of new drugs of target therapy in hormone dependent prostate cancer. Materials and Methods: Standard prostatic cancer cell line (PC-3) was injected heterotopically into 9 nude mice. After tumor formation they were excised and sent for histopathologic and AR expression studies by immunohistochemistry. Results: Histological characteristics of prostate cancer were confirmed. Androgen receptors had been expressed in 65 ± 25% of the xenograft tumor cells. Conclusions: This xenograft model is suitable for pharmacological and molecular studies of androgen dependent prostate cancer. https://bccr.tums.ac.ir/index.php/bccrj/article/view/19 https://bccr.tums.ac.ir/index.php/bccrj/article/download/19/18