Tehran University of Medical Sciences Basic & Clinical Cancer Research 2228-6527 8 1&2 2016 08 03 28 35 EN Zeinab Hemati PhD candidate of nursing, Nursing and Midwifery Care Research Center, faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran Davood Kiani MSc of Nursing, Shahrekord University of Medical Sciences, Shahrekord, Iran 2015 12 06 2016 07 03 Background: self- esteem is defined as the reliance of one's own abilities. Decrees of self- esteem may lead to fail to solve the problems not being able to use ones abilities. So, this study was done to compare TIP patients' self- esteem with healthy cases. The conduction of this investigation seems to be important, because this disease a chronic type.        Methods: This is a descriptive- comparative study in which 64 patients having ITP and referring to Isfahan's Seiyedo-shohada hospital and 65 healthy people who were neighbors of these patients. They were also selected randomly. The data collection method included questionnaire of Cooper Smiths self- esteem which was completed by the cases. The data analyzed through Spss version 15, and by use of T-independent, K-Squer and Man Withny test.  Results: This study's results showed that 64.1, 59.4 and 53.1 percent of the cases in both group were, in turn, over 35 years old. Females and graduated from primary school. T-independent test, showed significant difference between both groups self-esteem average. (p<0.01) Conclusion: Since the self-esteem of the patients is low and patient's decision making ability and their controls over the disease affect their self-esteem important, health and treatment staffs are supposed to recognize significant factors affecting self- valuing feeling and help the patient to promote their self- esteem. https://bccr.tums.ac.ir/index.php/bccrj/article/view/178 https://bccr.tums.ac.ir/index.php/bccrj/article/download/178/03